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Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity.
De Bellis M, Carbonara R, Roussel J, Farinato A, Massari A, Pierno S, Muraglia M, Corbo F, Franchini C, Carratù MR, De Luca A, Conte Camerino D, Desaphy JF. De Bellis M, et al. Among authors: franchini c. Neuropharmacology. 2017 Feb;113(Pt A):206-216. doi: 10.1016/j.neuropharm.2016.10.013. Epub 2016 Oct 13. Neuropharmacology. 2017. PMID: 27743929 Free PMC article.
Searching for novel anti-myotonic agents: pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide.
De Luca A, De Bellis M, Corbo F, Franchini C, Muraglia M, Catalano A, Carocci A, Camerino DC. De Luca A, et al. Among authors: franchini c. Neuromuscul Disord. 2012 Jan;22(1):56-65. doi: 10.1016/j.nmd.2011.07.001. Epub 2011 Jul 29. Neuromuscul Disord. 2012. PMID: 21802953 Free PMC article.
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo.
Talon S, De Luca A, De Bellis M, Desaphy JF, Lentini G, Scilimati A, Corbo F, Franchini C, Tortorella P, Jockusch H, Conte Camerino D. Talon S, et al. Among authors: franchini c. Br J Pharmacol. 2001 Dec;134(7):1523-31. doi: 10.1038/sj.bjp.0704366. Br J Pharmacol. 2001. PMID: 11724759 Free PMC article.
Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile.
De Luca A, Talon S, De Bellis M, Desaphy JF, Franchini C, Lentini G, Catalano A, Corbo F, Tortorella V, Conte-Camerino D. De Luca A, et al. Among authors: franchini c. Naunyn Schmiedebergs Arch Pharmacol. 2003 Mar;367(3):318-27. doi: 10.1007/s00210-002-0669-0. Epub 2003 Jan 25. Naunyn Schmiedebergs Arch Pharmacol. 2003. PMID: 12644906
211 results