Zoghbi HY - Search Results

1

TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau.

Rousseaux MW, de Haro M, Lasagna-Reeves CA, De Maio A, Park J, Jafar-Nejad P, Al-Ramahi I, Sharma A, See L, Lu N, Vilanova-Velez L, Klisch TJ, Westbrook TF, Troncoso JC, Botas J, Zoghbi HY. Rousseaux MW, et al. Among authors: zoghbi hy. Elife. 2016 Oct 25;5:e19809. doi: 10.7554/eLife.19809. Elife. 2016. PMID: 27779468 Free PMC article.

2

Mouse and fly models of neurodegeneration.

Zoghbi HY, Botas J. Zoghbi HY, et al. Trends Genet. 2002 Sep;18(9):463-71. doi: 10.1016/s0168-9525(02)02729-4. Trends Genet. 2002. PMID: 12175807 Review.

3

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

Chen HK, Fernandez-Funez P, Acevedo SF, Lam YC, Kaytor MD, Fernandez MH, Aitken A, Skoulakis EM, Orr HT, Botas J, Zoghbi HY. Chen HK, et al. Among authors: zoghbi hy. Cell. 2003 May 16;113(4):457-68. doi: 10.1016/s0092-8674(03)00349-0. Cell. 2003. PMID: 12757707 Free article.

4

The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins.

Tsuda H, Jafar-Nejad H, Patel AJ, Sun Y, Chen HK, Rose MF, Venken KJ, Botas J, Orr HT, Bellen HJ, Zoghbi HY. Tsuda H, et al. Among authors: zoghbi hy. Cell. 2005 Aug 26;122(4):633-44. doi: 10.1016/j.cell.2005.06.012. Cell. 2005. PMID: 16122429 Free article.

5

CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation.

Al-Ramahi I, Lam YC, Chen HK, de Gouyon B, Zhang M, Pérez AM, Branco J, de Haro M, Patterson C, Zoghbi HY, Botas J. Al-Ramahi I, et al. Among authors: zoghbi hy. J Biol Chem. 2006 Sep 8;281(36):26714-24. doi: 10.1074/jbc.M601603200. Epub 2006 Jul 10. J Biol Chem. 2006. PMID: 16831871 Free article.

6

ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology.

Lam YC, Bowman AB, Jafar-Nejad P, Lim J, Richman R, Fryer JD, Hyun ED, Duvick LA, Orr HT, Botas J, Zoghbi HY. Lam YC, et al. Among authors: zoghbi hy. Cell. 2006 Dec 29;127(7):1335-47. doi: 10.1016/j.cell.2006.11.038. Cell. 2006. PMID: 17190598 Free article.

7

Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes.

Bowman AB, Lam YC, Jafar-Nejad P, Chen HK, Richman R, Samaco RC, Fryer JD, Kahle JJ, Orr HT, Zoghbi HY. Bowman AB, et al. Among authors: zoghbi hy. Nat Genet. 2007 Mar;39(3):373-9. doi: 10.1038/ng1977. Epub 2007 Feb 18. Nat Genet. 2007. PMID: 17322884

8

dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1.

Al-Ramahi I, Pérez AM, Lim J, Zhang M, Sorensen R, de Haro M, Branco J, Pulst SM, Zoghbi HY, Botas J. Al-Ramahi I, et al. Among authors: zoghbi hy. PLoS Genet. 2007 Dec 28;3(12):e234. doi: 10.1371/journal.pgen.0030234. Epub 2007 Nov 16. PLoS Genet. 2007. PMID: 18166084 Free PMC article.

9

The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7.

Gatchel JR, Watase K, Thaller C, Carson JP, Jafar-Nejad P, Shaw C, Zu T, Orr HT, Zoghbi HY. Gatchel JR, et al. Among authors: zoghbi hy. Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1291-6. doi: 10.1073/pnas.0711257105. Epub 2008 Jan 23. Proc Natl Acad Sci U S A. 2008. PMID: 18216249 Free PMC article.

10

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1.

Lim J, Crespo-Barreto J, Jafar-Nejad P, Bowman AB, Richman R, Hill DE, Orr HT, Zoghbi HY. Lim J, et al. Among authors: zoghbi hy. Nature. 2008 Apr 10;452(7188):713-8. doi: 10.1038/nature06731. Epub 2008 Mar 12. Nature. 2008. PMID: 18337722 Free PMC article.

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