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Page 1
Sequential C-H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD-1 Inhibitor.
Wei X, Qu B, Zeng X, Savoie J, Fandrick KR, Desrosiers JN, Tcyrulnikov S, Marsini MA, Buono FG, Li Z, Yang BS, Tang W, Haddad N, Gutierrez O, Wang J, Lee H, Ma S, Campbell S, Lorenz JC, Eckhardt M, Himmelsbach F, Peters S, Patel ND, Tan Z, Yee NK, Song JJ, Roschangar F, Kozlowski MC, Senanayake CH. Wei X, et al. Among authors: patel nd. J Am Chem Soc. 2016 Nov 30;138(47):15473-15481. doi: 10.1021/jacs.6b09764. Epub 2016 Nov 17. J Am Chem Soc. 2016. PMID: 27794616 Free PMC article.
Development of an asymmetric synthesis of a chiral quaternary FLAP inhibitor.
Fandrick KR, Mulder JA, Patel ND, Gao J, Konrad M, Archer E, Buono FG, Duran A, Schmid R, Daeubler J, Desrosiers JN, Zeng X, Rodriguez S, Ma S, Qu B, Li Z, Fandrick DR, Grinberg N, Lee H, Bosanac T, Takahashi H, Chen Z, Bartolozzi A, Nemoto P, Busacca CA, Song JJ, Yee NK, Mahaney PE, Senanayake CH. Fandrick KR, et al. Among authors: patel nd. J Org Chem. 2015 Feb 6;80(3):1651-60. doi: 10.1021/jo502550h. Epub 2015 Jan 22. J Org Chem. 2015. PMID: 25562342
Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki-Miyaura and Negishi Cross-Coupling Reactions for Tetra-ortho-Substituted Biaryl Synthesis.
Patel ND, Sieber JD, Tcyrulnikov S, Simmons BJ, Rivalti D, Duvvuri K, Zhang Y, Gao DA, Fandrick KR, Haddad N, Lao KS, Mangunuru HPR, Biswas S, Qu B, Grinberg N, Pennino S, Lee H, Song JJ, Gupton BF, Garg NK, Kozlowski MC, Senanayake CH. Patel ND, et al. ACS Catal. 2018 Nov 2;8(11):10190-10209. doi: 10.1021/acscatal.8b02509. Epub 2018 Sep 20. ACS Catal. 2018. PMID: 30450265 Free PMC article.
A general and special catalyst for Suzuki-Miyaura coupling processes.
Tang W, Capacci AG, Wei X, Li W, White A, Patel ND, Savoie J, Gao JJ, Rodriguez S, Qu B, Haddad N, Lu BZ, Krishnamurthy D, Yee NK, Senanayake CH. Tang W, et al. Among authors: patel nd. Angew Chem Int Ed Engl. 2010 Aug 9;49(34):5879-83. doi: 10.1002/anie.201002404. Angew Chem Int Ed Engl. 2010. PMID: 20632427 No abstract available.
Addressing the configuration stability of lithiated secondary benzylic carbamates for the development of a noncryogenic stereospecific boronate rearrangement.
Fandrick KR, Patel ND, Mulder JA, Gao J, Konrad M, Archer E, Buono FG, Duran A, Schmid R, Daeubler J, Fandrick DR, Ma S, Grinberg N, Lee H, Busacca CA, Song JJ, Yee NK, Senanayake CH. Fandrick KR, et al. Among authors: patel nd. Org Lett. 2014 Sep 5;16(17):4360-3. doi: 10.1021/ol502060c. Epub 2014 Aug 25. Org Lett. 2014. PMID: 25153850
Efficient asymmetric synthesis of structurally diverse P-stereogenic phosphinamides for catalyst design.
Han ZS, Zhang L, Xu Y, Sieber JD, Marsini MA, Li Z, Reeves JT, Fandrick KR, Patel ND, Desrosiers JN, Qu B, Chen A, Rudzinski DM, Samankumara LP, Ma S, Grinberg N, Roschangar F, Yee NK, Wang G, Song JJ, Senanayake CH. Han ZS, et al. Among authors: patel nd. Angew Chem Int Ed Engl. 2015 Apr 27;54(18):5474-7. doi: 10.1002/anie.201500350. Epub 2015 Mar 10. Angew Chem Int Ed Engl. 2015. PMID: 25757595
Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor.
Fandrick KR, Li W, Zhang Y, Tang W, Gao J, Rodriguez S, Patel ND, Reeves DC, Wu JP, Sanyal S, Gonnella N, Qu B, Haddad N, Lorenz JC, Sidhu K, Wang J, Ma S, Grinberg N, Lee H, Tsantrizos Y, Poupart MA, Busacca CA, Yee NK, Lu BZ, Senanayake CH. Fandrick KR, et al. Among authors: patel nd. Angew Chem Int Ed Engl. 2015 Jun 8;54(24):7144-8. doi: 10.1002/anie.201501575. Epub 2015 May 4. Angew Chem Int Ed Engl. 2015. PMID: 25939331
348 results