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Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice.
Ishikura T, Kanai T, Uraushihara K, Iiyama R, Makita S, Totsuka T, Yamazaki M, Sawada T, Nakamura T, Miyata T, Kitahora T, Hibi T, Hoshino T, Watanabe M. Ishikura T, et al. Among authors: watanabe m. J Gastroenterol Hepatol. 2003 Aug;18(8):960-9. doi: 10.1046/j.1440-1746.2003.03097.x. J Gastroenterol Hepatol. 2003. PMID: 12859727
Blockade of B7-H1 suppresses the development of chronic intestinal inflammation.
Kanai T, Totsuka T, Uraushihara K, Makita S, Nakamura T, Koganei K, Fukushima T, Akiba H, Yagita H, Okumura K, Machida U, Iwai H, Azuma M, Chen L, Watanabe M. Kanai T, et al. Among authors: watanabe m. J Immunol. 2003 Oct 15;171(8):4156-63. doi: 10.4049/jimmunol.171.8.4156. J Immunol. 2003. PMID: 14530338
Macrophage-derived IL-18 targeting for the treatment of Crohn's disease.
Kanai T, Uraushihara K, Totsuka T, Okazawa A, Hibi T, Oshima S, Miyata T, Nakamura T, Watanabe M. Kanai T, et al. Among authors: watanabe m. Curr Drug Targets Inflamm Allergy. 2003 Jun;2(2):131-6. doi: 10.2174/1568010033484250. Curr Drug Targets Inflamm Allergy. 2003. PMID: 14561165 Review.
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