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An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability.
van Gils MJ, van den Kerkhof TL, Ozorowski G, Cottrell CA, Sok D, Pauthner M, Pallesen J, de Val N, Yasmeen A, de Taeye SW, Schorcht A, Gumbs S, Johanna I, Saye-Francisco K, Liang CH, Landais E, Nie X, Pritchard LK, Crispin M, Kelsoe G, Wilson IA, Schuitemaker H, Klasse PJ, Moore JP, Burton DR, Ward AB, Sanders RW. van Gils MJ, et al. Among authors: sanders rw. Nat Microbiol. 2016 Nov 14;2:16199. doi: 10.1038/nmicrobiol.2016.199. Nat Microbiol. 2016. PMID: 27841852 Free PMC article.
A recombinant human immunodeficiency virus type 1 envelope glycoprotein complex stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits is an antigenic mimic of the trimeric virion-associated structure.
Binley JM, Sanders RW, Clas B, Schuelke N, Master A, Guo Y, Kajumo F, Anselma DJ, Maddon PJ, Olson WC, Moore JP. Binley JM, et al. Among authors: sanders rw. J Virol. 2000 Jan;74(2):627-43. doi: 10.1128/jvi.74.2.627-643.2000. J Virol. 2000. PMID: 10623724 Free PMC article.
447 results