Manas ES - Search Results

1

Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA₂).

Woolford AJ, Day PJ, Bénéton V, Berdini V, Coyle JE, Dudit Y, Grondin P, Huet P, Lee LY, Manas ES, McMenamin RL, Murray CW, Page LW, Patel VK, Potvain F, Rich SJ, Sang Y, Somers DO, Trottet L, Wan Z, Zhang X. Woolford AJ, et al. Among authors: manas es. J Med Chem. 2016 Dec 8;59(23):10738-10749. doi: 10.1021/acs.jmedchem.6b01427. Epub 2016 Nov 18. J Med Chem. 2016. PMID: 27933945

2

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.

Woolford AJ, Pero JE, Aravapalli S, Berdini V, Coyle JE, Day PJ, Dodson AM, Grondin P, Holding FP, Lee LY, Li P, Manas ES, Marino J Jr, Martin AC, McCleland BW, McMenamin RL, Murray CW, Neipp CE, Page LW, Patel VK, Potvain F, Rich S, Rivero RA, Smith K, Somers DO, Trottet L, Velagaleti R, Williams G, Xie R. Woolford AJ, et al. Among authors: manas es. J Med Chem. 2016 Jun 9;59(11):5356-67. doi: 10.1021/acs.jmedchem.6b00212. Epub 2016 May 20. J Med Chem. 2016. PMID: 27167608

3

Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA₂ Inhibitor.

Measom ND, Down KD, Hirst DJ, Jamieson C, Manas ES, Patel VK, Somers DO. Measom ND, et al. Among authors: manas es. ACS Med Chem Lett. 2016 Nov 15;8(1):43-48. doi: 10.1021/acsmedchemlett.6b00281. eCollection 2017 Jan 12. ACS Med Chem Lett. 2016. PMID: 28105273 Free PMC article.

4

Chemoselective One-Pot Synthesis of Functionalized Amino-azaheterocycles Enabled by COware.

Clohessy TA, Roberts A, Manas ES, Patel VK, Anderson NA, Watson AJB. Clohessy TA, et al. Among authors: manas es. Org Lett. 2017 Dec 1;19(23):6368-6371. doi: 10.1021/acs.orglett.7b03214. Epub 2017 Nov 14. Org Lett. 2017. PMID: 29135268

5

A Perspective on Water Site Prediction Methods for Structure Based Drug Design.

Graves AP, Wall ID, Edge CM, Woolven JM, Cui G, Le Gall A, Hong X, Raha K, Manas ES. Graves AP, et al. Among authors: manas es. Curr Top Med Chem. 2017;17(23):2599-2616. doi: 10.2174/1568026617666170427095035. Curr Top Med Chem. 2017. PMID: 28460610 Review.

6

Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols.

Kim CY, Mahaney PE, McConnell O, Zhang Y, Manas E, Ho DM, Deecher DC, Trybulski EJ. Kim CY, et al. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5029-32. doi: 10.1016/j.bmcl.2009.07.053. Epub 2009 Jul 23. Bioorg Med Chem Lett. 2009. PMID: 19632110

7

Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles.

Heffernan GD, Coghlan RD, Manas ES, McDevitt RE, Li Y, Mahaney PE, Robichaud AJ, Huselton C, Alfinito P, Bray JA, Cosmi SA, Johnston GH, Kenney T, Koury E, Winneker RC, Deecher DC, Trybulski EJ. Heffernan GD, et al. Among authors: manas es. Bioorg Med Chem. 2009 Nov 15;17(22):7802-15. doi: 10.1016/j.bmc.2009.09.023. Epub 2009 Sep 18. Bioorg Med Chem. 2009. PMID: 19836247

8

ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity.

Mewshaw RE, Edsall RJ Jr, Yang C, Manas ES, Xu ZB, Henderson RA, Keith JC Jr, Harris HA. Mewshaw RE, et al. Among authors: manas es. J Med Chem. 2005 Jun 16;48(12):3953-79. doi: 10.1021/jm058173s. J Med Chem. 2005. PMID: 15943471

9

ERbeta ligands. Part 2: Synthesis and structure-activity relationships of a series of 4-hydroxy-biphenyl-carbaldehyde oxime derivatives.

Yang C, Edsall R Jr, Harris HA, Zhang X, Manas ES, Mewshaw RE. Yang C, et al. Among authors: manas es. Bioorg Med Chem. 2004 May 15;12(10):2553-70. doi: 10.1016/j.bmc.2004.03.028. Bioorg Med Chem. 2004. PMID: 15110838

10

ERbeta ligands. Part 5: synthesis and structure-activity relationships of a series of 4'-hydroxyphenyl-aryl-carbaldehyde oxime derivatives.

Mewshaw RE, Bowen SM, Harris HA, Xu ZB, Manas ES, Cohn ST. Mewshaw RE, et al. Among authors: manas es. Bioorg Med Chem Lett. 2007 Feb 15;17(4):902-6. doi: 10.1016/j.bmcl.2006.11.066. Epub 2006 Dec 1. Bioorg Med Chem Lett. 2007. PMID: 17188490

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