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PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.
Anderson GR, Wardell SE, Cakir M, Crawford L, Leeds JC, Nussbaum DP, Shankar PS, Soderquist RS, Stein EM, Tingley JP, Winter PS, Zieser-Misenheimer EK, Alley HM, Yllanes A, Haney V, Blackwell KL, McCall SJ, McDonnell DP, Wood KC. Anderson GR, et al. Among authors: mcdonnell dp. Sci Transl Med. 2016 Dec 14;8(369):369ra175. doi: 10.1126/scitranslmed.aae0348. Sci Transl Med. 2016. PMID: 27974663 Free PMC article.
Glucose metabolism as a target of histone deacetylase inhibitors.
Wardell SE, Ilkayeva OR, Wieman HL, Frigo DE, Rathmell JC, Newgard CB, McDonnell DP. Wardell SE, et al. Among authors: mcdonnell dp. Mol Endocrinol. 2009 Mar;23(3):388-401. doi: 10.1210/me.2008-0179. Epub 2008 Dec 23. Mol Endocrinol. 2009. PMID: 19106193 Free PMC article.
27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.
Nelson ER, Wardell SE, Jasper JS, Park S, Suchindran S, Howe MK, Carver NJ, Pillai RV, Sullivan PM, Sondhi V, Umetani M, Geradts J, McDonnell DP. Nelson ER, et al. Among authors: mcdonnell dp. Science. 2013 Nov 29;342(6162):1094-8. doi: 10.1126/science.1241908. Science. 2013. PMID: 24288332 Free PMC article.
Obesity, cholesterol metabolism, and breast cancer pathogenesis.
McDonnell DP, Park S, Goulet MT, Jasper J, Wardell SE, Chang CY, Norris JD, Guyton JR, Nelson ER. McDonnell DP, et al. Cancer Res. 2014 Sep 15;74(18):4976-82. doi: 10.1158/0008-5472.CAN-14-1756. Epub 2014 Jul 24. Cancer Res. 2014. PMID: 25060521 Free PMC article.
295 results