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Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice.
El Khoury NB, Gratuze M, Petry F, Papon MA, Julien C, Marcouiller F, Morin F, Nicholls SB, Calon F, Hébert SS, Marette A, Planel E. El Khoury NB, et al. Among authors: nicholls sb. Neurobiol Dis. 2016 Apr;88:55-65. doi: 10.1016/j.nbd.2016.01.005. Epub 2016 Jan 9. Neurobiol Dis. 2016. PMID: 26777665
Experimental evidence for the age dependence of tau protein spread in the brain.
Wegmann S, Bennett RE, Delorme L, Robbins AB, Hu M, McKenzie D, Kirk MJ, Schiantarelli J, Tunio N, Amaral AC, Fan Z, Nicholls S, Hudry E, Hyman BT. Wegmann S, et al. Sci Adv. 2019 Jun 26;5(6):eaaw6404. doi: 10.1126/sciadv.aaw6404. eCollection 2019 Jun. Sci Adv. 2019. PMID: 31249873 Free PMC article.
Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.
Takeda S, Commins C, DeVos SL, Nobuhara CK, Wegmann S, Roe AD, Costantino I, Fan Z, Nicholls SB, Sherman AE, Trisini Lipsanopoulos AT, Scherzer CR, Carlson GA, Pitstick R, Peskind ER, Raskind MA, Li G, Montine TJ, Frosch MP, Hyman BT. Takeda S, et al. Among authors: nicholls sb. Ann Neurol. 2016 Sep;80(3):355-67. doi: 10.1002/ana.24716. Epub 2016 Aug 3. Ann Neurol. 2016. PMID: 27351289 Free PMC article.
Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity.
Wegmann S, Maury EA, Kirk MJ, Saqran L, Roe A, DeVos SL, Nicholls S, Fan Z, Takeda S, Cagsal-Getkin O, William CM, Spires-Jones TL, Pitstick R, Carlson GA, Pooler AM, Hyman BT. Wegmann S, et al. EMBO J. 2015 Dec 14;34(24):3028-41. doi: 10.15252/embj.201592748. Epub 2015 Nov 4. EMBO J. 2015. PMID: 26538322 Free PMC article.
25 results