Larsen SD - Search Results

1

Optimisation of Intestinal Fibrosis and Survival in the Mouse S. Typhimurium Model for Anti-fibrotic Drug Discovery and Preclinical Applications.

Johnson LA, Rodansky ES, Moons DS, Larsen SD, Neubig RR, Higgins PDR. Johnson LA, et al. Among authors: larsen sd. J Crohns Colitis. 2017 Jun 1;11(6):724-736. doi: 10.1093/ecco-jcc/jjw210. J Crohns Colitis. 2017. PMID: 27986839 Free PMC article.

2

Identification of thieno[3,2-b]pyrrole derivatives as novel small molecule inhibitors of neurotropic alphaviruses.

Peng W, Peltier DC, Larsen MJ, Kirchhoff PD, Larsen SD, Neubig RR, Miller DJ. Peng W, et al. Among authors: larsen sd, larsen mj. J Infect Dis. 2009 Apr 1;199(7):950-7. doi: 10.1086/597275. J Infect Dis. 2009. PMID: 19239364 Free PMC article.

3

Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423.

Evelyn CR, Bell JL, Ryu JG, Wade SM, Kocab A, Harzdorf NL, Showalter HD, Neubig RR, Larsen SD. Evelyn CR, et al. Among authors: larsen sd. Bioorg Med Chem Lett. 2010 Jan 15;20(2):665-72. doi: 10.1016/j.bmcl.2009.11.056. Epub 2009 Nov 18. Bioorg Med Chem Lett. 2010. PMID: 19963382 Free PMC article.

4

Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response.

Fribley AM, Cruz PG, Miller JR, Callaghan MU, Cai P, Narula N, Neubig RR, Showalter HD, Larsen SD, Kirchhoff PD, Larsen MJ, Burr DA, Schultz PJ, Jacobs RR, Tamayo-Castillo G, Ron D, Sherman DH, Kaufman RJ. Fribley AM, et al. Among authors: larsen sd, larsen mj. J Biomol Screen. 2011 Sep;16(8):825-35. doi: 10.1177/1087057111414893. Epub 2011 Aug 15. J Biomol Screen. 2011. PMID: 21844328 Free PMC article.

5

MScreen: an integrated compound management and high-throughput screening data storage and analysis system.

Jacob RT, Larsen MJ, Larsen SD, Kirchhoff PD, Sherman DH, Neubig RR. Jacob RT, et al. Among authors: larsen sd, larsen mj. J Biomol Screen. 2012 Sep;17(8):1080-7. doi: 10.1177/1087057112450186. Epub 2012 Jun 15. J Biomol Screen. 2012. PMID: 22706349 Free PMC article.

6

Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents.

Bell JL, Haak AJ, Wade SM, Kirchhoff PD, Neubig RR, Larsen SD. Bell JL, et al. Among authors: larsen sd. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3826-32. doi: 10.1016/j.bmcl.2013.04.080. Epub 2013 May 7. Bioorg Med Chem Lett. 2013. PMID: 23707258 Free PMC article.

7

Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway.

Bell JL, Haak AJ, Wade SM, Sun Y, Neubig RR, Larsen SD. Bell JL, et al. Among authors: larsen sd. Beilstein J Org Chem. 2013 May 21;9:966-73. doi: 10.3762/bjoc.9.111. Print 2013. Beilstein J Org Chem. 2013. PMID: 23766813 Free PMC article.

8

Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts.

Johnson LA, Rodansky ES, Haak AJ, Larsen SD, Neubig RR, Higgins PD. Johnson LA, et al. Among authors: larsen sd. Inflamm Bowel Dis. 2014 Jan;20(1):154-65. doi: 10.1097/01.MIB.0000437615.98881.31. Inflamm Bowel Dis. 2014. PMID: 24280883 Free PMC article.

9

Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.

Lundquist MR, Storaska AJ, Liu TC, Larsen SD, Evans T, Neubig RR, Jaffrey SR. Lundquist MR, et al. Among authors: larsen sd. Cell. 2014 Jan 30;156(3):563-76. doi: 10.1016/j.cell.2013.12.035. Epub 2014 Jan 16. Cell. 2014. PMID: 24440334 Free PMC article.

10

Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury.

Haak AJ, Tsou PS, Amin MA, Ruth JH, Campbell P, Fox DA, Khanna D, Larsen SD, Neubig RR. Haak AJ, et al. Among authors: larsen sd. J Pharmacol Exp Ther. 2014 Jun;349(3):480-6. doi: 10.1124/jpet.114.213520. Epub 2014 Apr 4. J Pharmacol Exp Ther. 2014. PMID: 24706986 Free PMC article.

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