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H255Y and K508R missense mutations in tumour suppressor folliculin (FLCN) promote kidney cell proliferation.
Hasumi H, Hasumi Y, Baba M, Nishi H, Furuya M, Vocke CD, Lang M, Irie N, Esumi C, Merino MJ, Kawahara T, Isono Y, Makiyama K, Warner AC, Haines DC, Wei MH, Zbar B, Hagenau H, Feigenbaum L, Kondo K, Nakaigawa N, Yao M, Metwalli AR, Marston Linehan W, Schmidt LS. Hasumi H, et al. Among authors: kondo k. Hum Mol Genet. 2017 Jan 15;26(2):354-366. doi: 10.1093/hmg/ddw392. Hum Mol Genet. 2017. PMID: 28007907 Free PMC article.
BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of variants in chromatin remodeling genes.
Hasumi H, Furuya M, Tatsuno K, Yamamoto S, Baba M, Hasumi Y, Isono Y, Suzuki K, Jikuya R, Otake S, Muraoka K, Osaka K, Hayashi N, Makiyama K, Miyoshi Y, Kondo K, Nakaigawa N, Kawahara T, Izumi K, Teranishi J, Yumura Y, Uemura H, Nagashima Y, Metwalli AR, Schmidt LS, Aburatani H, Linehan WM, Yao M. Hasumi H, et al. Among authors: kondo k. Hum Mol Genet. 2018 Aug 1;27(15):2712-2724. doi: 10.1093/hmg/ddy181. Hum Mol Genet. 2018. PMID: 29767721 Free PMC article.
Tumor signatures of PTHLH overexpression, high serum calcium, and poor prognosis were observed exclusively in clear cell but not non clear cell renal carcinomas.
Yao M, Murakami T, Shioi K, Mizuno N, Ito H, Kondo K, Hasumi H, Sano F, Makiyama K, Nakaigawa N, Kishida T, Nagashima Y, Yamanaka S, Kubota Y. Yao M, et al. Among authors: kondo k. Cancer Med. 2014 Aug;3(4):845-54. doi: 10.1002/cam4.270. Epub 2014 May 26. Cancer Med. 2014. PMID: 24861371 Free PMC article.
Complete response of hereditary leiomyomatosis and renal cell cancer (HLRCC)-associated renal cell carcinoma to nivolumab and ipilimumab combination immunotherapy by: a case report.
Iribe Y, Furuya M, Shibata Y, Yasui M, Funahashi M, Ota J, Iwashita H, Nagashima Y, Hasumi H, Hayashi N, Makiyama K, Kondo K, Tanaka R, Yao M, Nakaigawa N. Iribe Y, et al. Among authors: kondo k. Fam Cancer. 2021 Jan;20(1):75-80. doi: 10.1007/s10689-020-00195-0. Epub 2020 Jul 15. Fam Cancer. 2021. PMID: 32666341
Single-cell transcriptomes underscore genetically distinct tumor characteristics and microenvironment for hereditary kidney cancers.
Jikuya R, Murakami K, Nishiyama A, Kato I, Furuya M, Nakabayashi J, Ramilowski JA, Hamanoue H, Maejima K, Fujita M, Mitome T, Ohtake S, Noguchi G, Kawaura S, Odaka H, Kawahara T, Komeya M, Shinoki R, Ueno D, Ito H, Ito Y, Muraoka K, Hayashi N, Kondo K, Nakaigawa N, Hatano K, Baba M, Suda T, Kodama T, Fujii S, Makiyama K, Yao M, Shuch BM, Schmidt LS, Linehan WM, Nakagawa H, Tamura T, Hasumi H. Jikuya R, et al. Among authors: kondo k. iScience. 2022 May 25;25(6):104463. doi: 10.1016/j.isci.2022.104463. eCollection 2022 Jun 17. iScience. 2022. PMID: 35874919 Free PMC article.
PD-1 and PD-L1 are more highly expressed in high-grade bladder cancer than in low-grade cases: PD-L1 might function as a mediator of stage progression in bladder cancer.
Kawahara T, Ishiguro Y, Ohtake S, Kato I, Ito Y, Ito H, Makiyama K, Kondo K, Miyoshi Y, Yumura Y, Hayashi N, Hasumi H, Osaka K, Muraoka K, Izumi K, Teranishi JI, Uemura H, Yao M, Nakaigawa N. Kawahara T, et al. Among authors: kondo k. BMC Urol. 2018 Nov 6;18(1):97. doi: 10.1186/s12894-018-0414-8. BMC Urol. 2018. PMID: 30400941 Free PMC article.
4,341 results