Gao G - Search Results

1

PRMT5 C-terminal Phosphorylation Modulates a 14-3-3/PDZ Interaction Switch.

Espejo AB, Gao G, Black K, Gayatri S, Veland N, Kim J, Chen T, Sudol M, Walker C, Bedford MT. Espejo AB, et al. Among authors: gao g. J Biol Chem. 2017 Feb 10;292(6):2255-2265. doi: 10.1074/jbc.M116.760330. Epub 2016 Dec 28. J Biol Chem. 2017. PMID: 28031468 Free PMC article.

2

PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1.

Gao G, Dhar S, Bedford MT. Gao G, et al. Nucleic Acids Res. 2017 May 5;45(8):4359-4369. doi: 10.1093/nar/gkw1367. Nucleic Acids Res. 2017. PMID: 28115626 Free PMC article.

3

Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML.

Kaushik S, Liu F, Veazey KJ, Gao G, Das P, Neves LF, Lin K, Zhong Y, Lu Y, Giuliani V, Bedford MT, Nimer SD, Santos MA. Kaushik S, et al. Among authors: gao g. Leukemia. 2018 Feb;32(2):499-509. doi: 10.1038/leu.2017.206. Epub 2017 Jun 30. Leukemia. 2018. PMID: 28663579 Free PMC article.

4

PRMT1 loss sensitizes cells to PRMT5 inhibition.

Gao G, Zhang L, Villarreal OD, He W, Su D, Bedford E, Moh P, Shen J, Shi X, Bedford MT, Xu H. Gao G, et al. Nucleic Acids Res. 2019 Jun 4;47(10):5038-5048. doi: 10.1093/nar/gkz200. Nucleic Acids Res. 2019. PMID: 30916320 Free PMC article.

5

CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.

Veazey KJ, Cheng D, Lin K, Villarreal OD, Gao G, Perez-Oquendo M, Van HT, Stratton SA, Green M, Xu H, Lu Y, Bedford MT, Santos MA. Veazey KJ, et al. Among authors: gao g. Leukemia. 2020 Dec;34(12):3269-3285. doi: 10.1038/s41375-020-0908-8. Epub 2020 Jun 24. Leukemia. 2020. PMID: 32576962 Free PMC article.

6

Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders.

Shen Y, Gao G, Yu X, Kim H, Wang L, Xie L, Schwarz M, Chen X, Guccione E, Liu J, Bedford MT, Jin J. Shen Y, et al. Among authors: gao g. J Med Chem. 2020 Sep 10;63(17):9977-9989. doi: 10.1021/acs.jmedchem.0c01111. Epub 2020 Aug 21. J Med Chem. 2020. PMID: 32787082 Free PMC article.

7

Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6.

Cheng D, Gao G, Di Lorenzo A, Jayne S, Hottiger MO, Richard S, Bedford MT. Cheng D, et al. Among authors: gao g. J Biol Chem. 2020 Dec 11;295(50):17060-17070. doi: 10.1074/jbc.RA120.014704. Epub 2020 Oct 2. J Biol Chem. 2020. PMID: 33008887 Free PMC article.

8

SPINDOC binds PARP1 to facilitate PARylation.

Yang F, Chen J, Liu B, Gao G, Sebastian M, Jeter C, Shen J, Person MD, Bedford MT. Yang F, et al. Among authors: gao g. Nat Commun. 2021 Nov 4;12(1):6362. doi: 10.1038/s41467-021-26588-y. Nat Commun. 2021. PMID: 34737271 Free PMC article.

9

The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer.

Gao G, Hausmann S, Flores NM, Benitez AM, Shen J, Yang X, Person MD, Gayatri S, Cheng D, Lu Y, Liu B, Mazur PK, Bedford MT. Gao G, et al. Nat Commun. 2023 Jan 23;14(1):363. doi: 10.1038/s41467-023-35864-y. Nat Commun. 2023. PMID: 36690626 Free PMC article.

10

Inhibition of PRMT5 moderately suppresses prostate cancer growth in vivo but enhances its response to immunotherapy.

He Q, Zhang Y, Li W, Chen S, Xiong J, Zhao R, Yuan K, Hu Q, Liu S, Gao G, Bedford MT, Tang DG, Xu B, Zou C, Zhang D. He Q, et al. Among authors: gao g. Cancer Lett. 2024 Oct 10;602:217214. doi: 10.1016/j.canlet.2024.217214. Epub 2024 Aug 31. Cancer Lett. 2024. PMID: 39218291

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