Ismail S - Search Results

1

A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.

Martín-Gago P, Fansa EK, Klein CH, Murarka S, Janning P, Schürmann M, Metz M, Ismail S, Schultz-Fademrecht C, Baumann M, Bastiaens PI, Wittinghofer A, Waldmann H. Martín-Gago P, et al. Among authors: ismail s. Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2423-2428. doi: 10.1002/anie.201610957. Epub 2017 Jan 20. Angew Chem Int Ed Engl. 2017. PMID: 28106325

2

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo.

Ismail SA, Chen YX, Rusinova A, Chandra A, Bierbaum M, Gremer L, Triola G, Waldmann H, Bastiaens PI, Wittinghofer A. Ismail SA, et al. Nat Chem Biol. 2011 Oct 16;7(12):942-9. doi: 10.1038/nchembio.686. Nat Chem Biol. 2011. PMID: 22002721

3

Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3.

Kapoor S, Fansa EK, Möbitz S, Ismail SA, Winter R, Wittinghofer A, Weise K. Kapoor S, et al. Among authors: ismail sa. Biophys J. 2015 Oct 20;109(8):1619-29. doi: 10.1016/j.bpj.2015.08.033. Biophys J. 2015. PMID: 26488653 Free PMC article.

4

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling.

Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PI, Waldmann H. Zimmermann G, et al. Among authors: ismail s. Nature. 2013 May 30;497(7451):638-42. doi: 10.1038/nature12205. Epub 2013 May 22. Nature. 2013. PMID: 23698361

5

Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site.

Zimmermann G, Schultz-Fademrecht C, Küchler P, Murarka S, Ismail S, Triola G, Nussbaumer P, Wittinghofer A, Waldmann H. Zimmermann G, et al. Among authors: ismail s. J Med Chem. 2014 Jun 26;57(12):5435-48. doi: 10.1021/jm500632s. Epub 2014 Jun 11. J Med Chem. 2014. PMID: 24884780

6

The N- and C-terminal ends of RPGR can bind to PDE6δ.

Fansa EK, O'Reilly NJ, Ismail S, Wittinghofer A. Fansa EK, et al. Among authors: ismail s. EMBO Rep. 2015 Dec;16(12):1583-5. doi: 10.15252/embr.201541404. Epub 2015 Nov 9. EMBO Rep. 2015. PMID: 26553937 Free PMC article.

7

PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity.

Fansa EK, Kösling SK, Zent E, Wittinghofer A, Ismail S. Fansa EK, et al. Among authors: ismail s. Nat Commun. 2016 Apr 11;7:11366. doi: 10.1038/ncomms11366. Nat Commun. 2016. PMID: 27063844 Free PMC article.

8

Identification of pyrazolopyridazinones as PDEδ inhibitors.

Papke B, Murarka S, Vogel HA, Martín-Gago P, Kovacevic M, Truxius DC, Fansa EK, Ismail S, Zimmermann G, Heinelt K, Schultz-Fademrecht C, Al Saabi A, Baumann M, Nussbaumer P, Wittinghofer A, Waldmann H, Bastiaens PI. Papke B, et al. Among authors: ismail s. Nat Commun. 2016 Apr 20;7:11360. doi: 10.1038/ncomms11360. Nat Commun. 2016. PMID: 27094677 Free PMC article.

9

Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site.

Murarka S, Martín-Gago P, Schultz-Fademrecht C, Al Saabi A, Baumann M, Fansa EK, Ismail S, Nussbaumer P, Wittinghofer A, Waldmann H. Murarka S, et al. Among authors: ismail s. Chemistry. 2017 May 2;23(25):6083-6093. doi: 10.1002/chem.201603222. Epub 2016 Nov 3. Chemistry. 2017. PMID: 27809361

10

The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo.

Wätzlich D, Vetter I, Gotthardt K, Miertzschke M, Chen YX, Wittinghofer A, Ismail S. Wätzlich D, et al. Among authors: ismail s. EMBO Rep. 2013 May;14(5):465-72. doi: 10.1038/embor.2013.37. Epub 2013 Apr 5. EMBO Rep. 2013. PMID: 23559067 Free PMC article.

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