Cheng G - Search Results

1

Preclinical characterization of the novel HCV NS3 protease inhibitor GS-9256.

Yang H, Yang C, Wang Y, Rhodes G, Robinson M, Cheng G, Qi X, Mo H, Tian Y, Pakdaman R, Sheng XC, Kim CU, Delaney WE 4th. Yang H, et al. Among authors: cheng g. Antivir Ther. 2017;22(5):413-420. doi: 10.3851/IMP3132. Epub 2017 Jan 20. Antivir Ther. 2017. PMID: 28106531

2

Novel mutations in a tissue culture-adapted hepatitis C virus strain improve infectious-virus stability and markedly enhance infection kinetics.

Pokrovskii MV, Bush CO, Beran RK, Robinson MF, Cheng G, Tirunagari N, Fenaux M, Greenstein AE, Zhong W, Delaney WE 4th, Paulson MS. Pokrovskii MV, et al. Among authors: cheng g. J Virol. 2011 Apr;85(8):3978-85. doi: 10.1128/JVI.01760-10. Epub 2011 Feb 2. J Virol. 2011. PMID: 21289124 Free PMC article.

3

Selection of clinically relevant protease inhibitor-resistant viruses using the genotype 2a hepatitis C virus infection system.

Cheng G, Chan K, Yang H, Corsa A, Pokrovskii M, Paulson M, Bahador G, Zhong W, Delaney W 4th. Cheng G, et al. Antimicrob Agents Chemother. 2011 May;55(5):2197-205. doi: 10.1128/AAC.01382-10. Epub 2011 Feb 28. Antimicrob Agents Chemother. 2011. PMID: 21357305 Free PMC article.

4

An adaptive mutation in NS2 is essential for efficient production of infectious 1b/2a chimeric hepatitis C virus in cell culture.

Chan K, Cheng G, Beran RK, Yang H, Appleby TC, Pokrovskii MV, Mo H, Zhong W, Delaney WE 4th. Chan K, et al. Among authors: cheng g. Virology. 2012 Jan 20;422(2):224-34. doi: 10.1016/j.virol.2011.10.022. Epub 2011 Nov 17. Virology. 2012. PMID: 22099378 Free article.

5

A phase 1, randomized, placebo-controlled, 3-day, dose-ranging study of GS-5885, an NS5A inhibitor, in patients with genotype 1 hepatitis C.

Lawitz EJ, Gruener D, Hill JM, Marbury T, Moorehead L, Mathias A, Cheng G, Link JO, Wong KA, Mo H, McHutchison JG, Brainard DM. Lawitz EJ, et al. Among authors: cheng g. J Hepatol. 2012 Jul;57(1):24-31. doi: 10.1016/j.jhep.2011.12.029. Epub 2012 Feb 5. J Hepatol. 2012. PMID: 22314425 Clinical Trial.

6

Development of robust hepatitis C virus genotype 4 subgenomic replicons.

Peng B, Yu M, Xu S, Lee YJ, Tian Y, Yang H, Chan K, Mo H, McHutchison J, Delaney W 4th, Cheng G. Peng B, et al. Among authors: cheng g. Gastroenterology. 2013 Jan;144(1):59-61.e6. doi: 10.1053/j.gastro.2012.09.033. Epub 2012 Sep 20. Gastroenterology. 2013. PMID: 23000598

7

Preclinical characterization of the novel hepatitis C virus NS3 protease inhibitor GS-9451.

Yang H, Robinson M, Corsa AC, Peng B, Cheng G, Tian Y, Wang Y, Pakdaman R, Shen M, Qi X, Mo H, Tay C, Krawczyk S, Sheng XC, Kim CU, Yang C, Delaney WE 4th. Yang H, et al. Among authors: cheng g. Antimicrob Agents Chemother. 2014;58(2):647-53. doi: 10.1128/AAC.00487-13. Epub 2013 Aug 12. Antimicrob Agents Chemother. 2014. PMID: 23939899 Free PMC article.

8

In vitro efficacy of approved and experimental antivirals against novel genotype 3 hepatitis C virus subgenomic replicons.

Yu M, Corsa AC, Xu S, Peng B, Gong R, Lee YJ, Chan K, Mo H, Delaney W 4th, Cheng G. Yu M, et al. Among authors: cheng g. Antiviral Res. 2013 Nov;100(2):439-45. doi: 10.1016/j.antiviral.2013.08.018. Epub 2013 Sep 5. Antiviral Res. 2013. PMID: 24013001

9

Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection.

Link JO, Taylor JG, Xu L, Mitchell M, Guo H, Liu H, Kato D, Kirschberg T, Sun J, Squires N, Parrish J, Kellar T, Yang ZY, Yang C, Matles M, Wang Y, Wang K, Cheng G, Tian Y, Mogalian E, Mondou E, Cornpropst M, Perry J, Desai MC. Link JO, et al. Among authors: cheng g. J Med Chem. 2014 Mar 13;57(5):2033-46. doi: 10.1021/jm401499g. Epub 2014 Jan 10. J Med Chem. 2014. PMID: 24320933 Clinical Trial.

10

Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.

Feng JY, Cheng G, Perry J, Barauskas O, Xu Y, Fenaux M, Eng S, Tirunagari N, Peng B, Yu M, Tian Y, Lee YJ, Stepan G, Lagpacan LL, Jin D, Hung M, Ku KS, Han B, Kitrinos K, Perron M, Birkus G, Wong KA, Zhong W, Kim CU, Carey A, Cho A, Ray AS. Feng JY, et al. Among authors: cheng g. Antimicrob Agents Chemother. 2014;58(4):1930-42. doi: 10.1128/AAC.02351-13. Epub 2014 Jan 13. Antimicrob Agents Chemother. 2014. PMID: 24419349 Free PMC article.

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