Horton BL - Search Results

1

The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment.

Williams JB, Horton BL, Zheng Y, Duan Y, Powell JD, Gajewski TF. Williams JB, et al. Among authors: horton bl. J Exp Med. 2017 Feb;214(2):381-400. doi: 10.1084/jem.20160485. Epub 2017 Jan 23. J Exp Med. 2017. PMID: 28115575 Free PMC article.

2

Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment.

Spranger S, Koblish HK, Horton B, Scherle PA, Newton R, Gajewski TF. Spranger S, et al. J Immunother Cancer. 2014 Feb 18;2:3. doi: 10.1186/2051-1426-2-3. eCollection 2014. J Immunother Cancer. 2014. PMID: 24829760 Free PMC article.

3

Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy.

Spranger S, Dai D, Horton B, Gajewski TF. Spranger S, et al. Cancer Cell. 2017 May 8;31(5):711-723.e4. doi: 10.1016/j.ccell.2017.04.003. Cancer Cell. 2017. PMID: 28486109 Free PMC article.

4

Intratumoral CD8⁺ T-cell Apoptosis Is a Major Component of T-cell Dysfunction and Impedes Antitumor Immunity.

Horton BL, Williams JB, Cabanov A, Spranger S, Gajewski TF. Horton BL, et al. Cancer Immunol Res. 2018 Jan;6(1):14-24. doi: 10.1158/2326-6066.CIR-17-0249. Epub 2017 Nov 2. Cancer Immunol Res. 2018. PMID: 29097422 Free PMC article.

5

Cancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment.

Gajewski TF, Corrales L, Williams J, Horton B, Sivan A, Spranger S. Gajewski TF, et al. Adv Exp Med Biol. 2017;1036:19-31. doi: 10.1007/978-3-319-67577-0_2. Adv Exp Med Biol. 2017. PMID: 29275462 Free PMC article. Review.

6

Back from the dead: TIL apoptosis in cancer immune evasion.

Horton BL, Gajewski TF. Horton BL, et al. Br J Cancer. 2018 Feb 6;118(3):309-311. doi: 10.1038/bjc.2017.483. Epub 2018 Jan 23. Br J Cancer. 2018. PMID: 29360810 Free PMC article. No abstract available.

7

Batf3⁺ DCs and the 4-1BB/4-1BBL axis are required at the effector phase in the tumor microenvironment for PD-1/PD-L1 blockade efficacy.

Ziblat A, Horton BL, Higgs EF, Hatogai K, Martinez A, Shapiro JW, Kim DEC, Zha Y, Sweis RF, Gajewski TF. Ziblat A, et al. Among authors: horton bl. Cell Rep. 2024 May 28;43(5):114141. doi: 10.1016/j.celrep.2024.114141. Epub 2024 Apr 23. Cell Rep. 2024. PMID: 38656869 Free PMC article.

8

Lack of CD8⁺ T cell effector differentiation during priming mediates checkpoint blockade resistance in non-small cell lung cancer.

Horton BL, Morgan DM, Momin N, Zagorulya M, Torres-Mejia E, Bhandarkar V, Wittrup KD, Love JC, Spranger S. Horton BL, et al. Sci Immunol. 2021 Oct 29;6(64):eabi8800. doi: 10.1126/sciimmunol.abi8800. Epub 2021 Oct 29. Sci Immunol. 2021. PMID: 34714687 Free PMC article.

9

Leveraging immune resistance archetypes in solid cancer to inform next-generation anticancer therapies.

Anderson KG, Braun DA, Buqué A, Gitto SB, Guerriero JL, Horton B, Keenan BP, Kim TS, Overacre-Delgoffe A, Ruella M, Triplett TA, Veeranki O, Verma V, Zhang F. Anderson KG, et al. J Immunother Cancer. 2023 Jun;11(6):e006533. doi: 10.1136/jitc-2022-006533. J Immunother Cancer. 2023. PMID: 37399356 Free PMC article.

10

Expansion of tumor-reactive CD8⁺ T cell clonotypes occurs in the spleen in response to immune checkpoint blockade.

Morgan DM, Horton BL, Bhandarkar V, Van R, Dinter T, Zagorulya M, Love JC, Spranger S. Morgan DM, et al. Among authors: horton bl. Sci Immunol. 2024 Sep 13;9(99):eadi3487. doi: 10.1126/sciimmunol.adi3487. Epub 2024 Sep 13. Sci Immunol. 2024. PMID: 39270006 Free PMC article.

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