Hartley JA - Search Results

1

Synthesis and in vitro evaluation of SG3227, a pyrrolobenzodiazepine dimer antibody-drug conjugate payload based on sibiromycin.

Kemp GC, Tiberghien AC, Patel NV, D'Hooge F, Nilapwar SM, Adams LR, Corbett S, Williams DG, Hartley JA, Howard PW. Kemp GC, et al. Among authors: hartley ja. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1154-1158. doi: 10.1016/j.bmcl.2017.01.074. Epub 2017 Jan 30. Bioorg Med Chem Lett. 2017. PMID: 28188066

2

Design, synthesis, and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2, 1-c][1,4]benzodiazepine system.

Wilson SC, Howard PW, Forrow SM, Hartley JA, Adams LJ, Jenkins TC, Kelland LR, Thurston DE. Wilson SC, et al. Among authors: hartley ja. J Med Chem. 1999 Oct 7;42(20):4028-41. doi: 10.1021/jm981124d. J Med Chem. 1999. PMID: 10514273

3

Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.

Gregson SJ, Howard PW, Hartley JA, Brooks NA, Adams LJ, Jenkins TC, Kelland LR, Thurston DE. Gregson SJ, et al. Among authors: hartley ja. J Med Chem. 2001 Mar 1;44(5):737-48. doi: 10.1021/jm001064n. J Med Chem. 2001. PMID: 11262084

4

Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents.

Thurston DE, Bose DS, Thompson AS, Howard PW, Leoni A, Croker SJ, Jenkins TC, Neidle S, Hartley JA, Hurley LH. Thurston DE, et al. Among authors: hartley ja. J Org Chem. 1996 Nov 15;61(23):8141-8147. doi: 10.1021/jo951631s. J Org Chem. 1996. PMID: 11667802

5

Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.

Gregson SJ, Howard PW, Gullick DR, Hamaguchi A, Corcoran KE, Brooks NA, Hartley JA, Jenkins TC, Patel S, Guille MJ, Thurston DE. Gregson SJ, et al. Among authors: hartley ja. J Med Chem. 2004 Feb 26;47(5):1161-74. doi: 10.1021/jm030897l. J Med Chem. 2004. PMID: 14971896

6

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.

Hartley JA, Spanswick VJ, Brooks N, Clingen PH, McHugh PJ, Hochhauser D, Pedley RB, Kelland LR, Alley MC, Schultz R, Hollingshead MG, Schweikart KM, Tomaszewski JE, Sausville EA, Gregson SJ, Howard PW, Thurston DE. Hartley JA, et al. Cancer Res. 2004 Sep 15;64(18):6693-9. doi: 10.1158/0008-5472.CAN-03-2941. Cancer Res. 2004. PMID: 15374986

7

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations.

Alley MC, Hollingshead MG, Pacula-Cox CM, Waud WR, Hartley JA, Howard PW, Gregson SJ, Thurston DE, Sausville EA. Alley MC, et al. Among authors: hartley ja. Cancer Res. 2004 Sep 15;64(18):6700-6. doi: 10.1158/0008-5472.CAN-03-2942. Cancer Res. 2004. PMID: 15374987

8

Azinomycin inspired bisepoxides: influence of linker structure on in vitro cytotoxicity and DNA interstrand cross-linking.

LePla RC, Landreau CA, Shipman M, Hartley JA, Jones GD. LePla RC, et al. Among authors: hartley ja. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2861-4. doi: 10.1016/j.bmcl.2005.03.091. Epub 2005 Apr 25. Bioorg Med Chem Lett. 2005. PMID: 15911269

9

Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy.

Masterson LA, Spanswick VJ, Hartley JA, Begent RH, Howard PW, Thurston DE. Masterson LA, et al. Among authors: hartley ja. Bioorg Med Chem Lett. 2006 Jan 15;16(2):252-6. doi: 10.1016/j.bmcl.2005.10.017. Epub 2005 Nov 15. Bioorg Med Chem Lett. 2006. PMID: 16290933

10

Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates.

Wells G, Martin CR, Howard PW, Sands ZA, Laughton CA, Tiberghien A, Woo CK, Masterson LA, Stephenson MJ, Hartley JA, Jenkins TC, Shnyder SD, Loadman PM, Waring MJ, Thurston DE. Wells G, et al. Among authors: hartley ja. J Med Chem. 2006 Sep 7;49(18):5442-61. doi: 10.1021/jm051199z. J Med Chem. 2006. PMID: 16942018

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