Romo D - Search Results

1

A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.

Zhu M, Harshbarger WD, Robles O, Krysiak J, Hull KG, Cho SW, Richardson RD, Yang Y, Garcia A, Spiegelman L, Ramirez B, Wilson CT, Yau JA, Moore JT, Walker CB, Sacchettini JC, Liu WR, Sieber SA, Smith JW, Romo D. Zhu M, et al. Among authors: romo d. Bioorg Med Chem. 2017 Jun 1;25(11):2901-2916. doi: 10.1016/j.bmc.2017.01.020. Epub 2017 Jan 19. Bioorg Med Chem. 2017. PMID: 28236510 Free PMC article.

2

Synthesis and inhibitory action on HMG-CoA synthase of racemic and optically active oxetan-2-ones (beta-lactones).

Romo D, Harrison PH, Jenkins SI, Riddoch RW, Park K, Yang HW, Zhao C, Wright GD. Romo D, et al. Bioorg Med Chem. 1998 Aug;6(8):1255-72. doi: 10.1016/s0968-0896(98)00114-x. Bioorg Med Chem. 1998. PMID: 9784867

3

Practical, catalytic, asymmetric synthesis of beta-lactones via a sequential ketene dimerization/hydrogenation process: inhibitors of the thioesterase domain of fatty acid synthase.

Purohit VC, Richardson RD, Smith JW, Romo D. Purohit VC, et al. Among authors: romo d. J Org Chem. 2006 Jun 9;71(12):4549-58. doi: 10.1021/jo060392d. J Org Chem. 2006. PMID: 16749788

4

Total synthesis and comparative analysis of orlistat, valilactone, and a transposed orlistat derivative: Inhibitors of fatty acid synthase.

Ma G, Zancanella M, Oyola Y, Richardson RD, Smith JW, Romo D. Ma G, et al. Among authors: romo d. Org Lett. 2006 Sep 28;8(20):4497-500. doi: 10.1021/ol061651o. Org Lett. 2006. PMID: 16986934

5

Total synthesis of (-)-belactosin C and derivatives via double diastereoselective tandem mukaiyama aldol lactonizations.

Cho SW, Romo D. Cho SW, et al. Among authors: romo d. Org Lett. 2007 Apr 12;9(8):1537-40. doi: 10.1021/ol070275k. Epub 2007 Mar 23. Org Lett. 2007. PMID: 17378572

6

Beta-lactam congeners of orlistat as inhibitors of fatty acid synthase.

Zhang W, Richardson RD, Chamni S, Smith JW, Romo D. Zhang W, et al. Among authors: romo d. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2491-4. doi: 10.1016/j.bmcl.2008.02.043. Epub 2008 Feb 19. Bioorg Med Chem Lett. 2008. PMID: 18343106

7

Synthesis of novel beta-lactone inhibitors of fatty acid synthase.

Richardson RD, Ma G, Oyola Y, Zancanella M, Knowles LM, Cieplak P, Romo D, Smith JW. Richardson RD, et al. Among authors: romo d. J Med Chem. 2008 Sep 11;51(17):5285-96. doi: 10.1021/jm800321h. Epub 2008 Aug 19. J Med Chem. 2008. PMID: 18710210 Free PMC article.

8

Bioinspired total synthesis and human proteasome inhibitory activity of (-)-salinosporamide A, (-)-homosalinosporamide A, and derivatives obtained via organonucleophile promoted bis-cyclizations.

Nguyen H, Ma G, Gladysheva T, Fremgen T, Romo D. Nguyen H, et al. Among authors: romo d. J Org Chem. 2011 Jan 7;76(1):2-12. doi: 10.1021/jo101638r. Epub 2010 Nov 3. J Org Chem. 2011. PMID: 21047113 Free PMC article.

9

Cyclopropanations of olefin-containing natural products for simultaneous arming and structure activity studies.

Robles O, Serna-Saldívar SO, Gutiérrez-Uribe JA, Romo D. Robles O, et al. Among authors: romo d. Org Lett. 2012 Mar 16;14(6):1394-7. doi: 10.1021/ol300105q. Epub 2012 Feb 24. Org Lett. 2012. PMID: 22360738 Free PMC article.

10

Concise synthesis of the isothiourea organocatalysts homobenzotetramisole and derivatives.

Ranieri B, Robles O, Romo D. Ranieri B, et al. Among authors: romo d. J Org Chem. 2013 Jun 21;78(12):6291-6. doi: 10.1021/jo400603n. Epub 2013 Jun 5. J Org Chem. 2013. PMID: 23688163

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