Pawson T - Search Results

1

The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression.

Ahn R, Sabourin V, Bolt AM, Hébert S, Totten S, De Jay N, Festa MC, Young YK, Im YK, Pawson T, Koromilas AE, Muller WJ, Mann KK, Kleinman CL, Ursini-Siegel J. Ahn R, et al. Among authors: pawson t. Nat Commun. 2017 Mar 9;8:14638. doi: 10.1038/ncomms14638. Nat Commun. 2017. PMID: 28276425 Free PMC article.

2

The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression.

Ahn R, Sabourin V, Ha JR, Cory S, Maric G, Im YK, Hardy WR, Zhao H, Park M, Hallett M, Siegel PM, Pawson T, Ursini-Siegel J. Ahn R, et al. Among authors: pawson t. Cancer Res. 2013 Jul 15;73(14):4521-32. doi: 10.1158/0008-5472.CAN-12-4178. Epub 2013 May 21. Cancer Res. 2013. PMID: 23695548

3

Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.

Im YK, Najyb O, Gravel SP, McGuirk S, Ahn R, Avizonis DZ, Chénard V, Sabourin V, Hudson J, Pawson T, Topisirovic I, Pollak M, St-Pierre J, Ursini-Siegel J. Im YK, et al. Among authors: pawson t. Cancer Res. 2018 Sep 1;78(17):4826-4838. doi: 10.1158/0008-5472.CAN-17-3696. Epub 2018 Jun 21. Cancer Res. 2018. PMID: 29930100

4

ShcA signalling is essential for tumour progression in mouse models of human breast cancer.

Ursini-Siegel J, Hardy WR, Zuo D, Lam SH, Sanguin-Gendreau V, Cardiff RD, Pawson T, Muller WJ. Ursini-Siegel J, et al. Among authors: pawson t. EMBO J. 2008 Mar 19;27(6):910-20. doi: 10.1038/emboj.2008.22. Epub 2008 Feb 14. EMBO J. 2008. PMID: 18273058 Free PMC article.

5

Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response.

Ursini-Siegel J, Cory S, Zuo D, Hardy WR, Rexhepaj E, Lam S, Schade B, Jirstrom K, Bjur E, Piccirillo CA, Denardo D, Coussens LM, Brennan DJ, Gallagher WM, Park M, Pawson T, Hallett M, Muller WJ. Ursini-Siegel J, et al. Among authors: pawson t. Cancer Res. 2010 Oct 15;70(20):7776-87. doi: 10.1158/0008-5472.CAN-10-2229. Epub 2010 Oct 5. Cancer Res. 2010. PMID: 20924104 Free PMC article.

6

The ShcA SH2 domain engages a 14-3-3/PI3'K signaling complex and promotes breast cancer cell survival.

Ursini-Siegel J, Hardy WR, Zheng Y, Ling C, Zuo D, Zhang C, Podmore L, Pawson T, Muller WJ. Ursini-Siegel J, et al. Among authors: pawson t. Oncogene. 2012 Nov 29;31(48):5038-44. doi: 10.1038/onc.2012.4. Epub 2012 Jan 30. Oncogene. 2012. PMID: 22286768

7

The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner.

Im YK, La Selva R, Gandin V, Ha JR, Sabourin V, Sonenberg N, Pawson T, Topisirovic I, Ursini-Siegel J. Im YK, et al. Among authors: pawson t. Oncogene. 2015 Mar 26;34(13):1729-35. doi: 10.1038/onc.2014.110. Epub 2014 May 19. Oncogene. 2015. PMID: 24837366

8

Temporal regulation of EGF signalling networks by the scaffold protein Shc1.

Zheng Y, Zhang C, Croucher DR, Soliman MA, St-Denis N, Pasculescu A, Taylor L, Tate SA, Hardy WR, Colwill K, Dai AY, Bagshaw R, Dennis JW, Gingras AC, Daly RJ, Pawson T. Zheng Y, et al. Among authors: pawson t. Nature. 2013 Jul 11;499(7457):166-71. doi: 10.1038/nature12308. Nature. 2013. PMID: 23846654 Free PMC article.

9

The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis.

Saucier C, Khoury H, Lai KM, Peschard P, Dankort D, Naujokas MA, Holash J, Yancopoulos GD, Muller WJ, Pawson T, Park M. Saucier C, et al. Among authors: pawson t. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2345-50. doi: 10.1073/pnas.0308065101. Proc Natl Acad Sci U S A. 2004. PMID: 14983012 Free PMC article.

10

Accelerated mammary tumor development in mutant polyomavirus middle T transgenic mice expressing elevated levels of either the Shc or Grb2 adapter protein.

Rauh MJ, Blackmore V, Andrechek ER, Tortorice CG, Daly R, Lai VK, Pawson T, Cardiff RD, Siegel PM, Muller WJ. Rauh MJ, et al. Among authors: pawson t. Mol Cell Biol. 1999 Dec;19(12):8169-79. doi: 10.1128/MCB.19.12.8169. Mol Cell Biol. 1999. PMID: 10567542 Free PMC article.

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