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The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries.
Grasso S, Chapelle J, Salemme V, Aramu S, Russo I, Vitale N, Verdun di Cantogno L, Dallaglio K, Castellano I, Amici A, Centonze G, Sharma N, Lunardi S, Cabodi S, Cavallo F, Lamolinara A, Stramucci L, Moiso E, Provero P, Albini A, Sapino A, Staaf J, Di Fiore PP, Bertalot G, Pece S, Tosoni D, Confalonieri S, Iezzi M, Di Stefano P, Turco E, Defilippi P. Grasso S, et al. Among authors: turco e. Nat Commun. 2017 Mar 16;8:14797. doi: 10.1038/ncomms14797. Nat Commun. 2017. PMID: 28300085 Free PMC article.
p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis.
Cabodi S, Tinnirello A, Di Stefano P, Bisarò B, Ambrosino E, Castellano I, Sapino A, Arisio R, Cavallo F, Forni G, Glukhova M, Silengo L, Altruda F, Turco E, Tarone G, Defilippi P. Cabodi S, et al. Among authors: turco e. Cancer Res. 2006 May 1;66(9):4672-80. doi: 10.1158/0008-5472.CAN-05-2909. Cancer Res. 2006. PMID: 16651418
Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.
Ciraolo E, Iezzi M, Marone R, Marengo S, Curcio C, Costa C, Azzolino O, Gonella C, Rubinetto C, Wu H, Dastrù W, Martin EL, Silengo L, Altruda F, Turco E, Lanzetti L, Musiani P, Rückle T, Rommel C, Backer JM, Forni G, Wymann MP, Hirsch E. Ciraolo E, et al. Among authors: turco e. Sci Signal. 2008 Sep 9;1(36):ra3. doi: 10.1126/scisignal.1161577. Sci Signal. 2008. PMID: 18780892 Free PMC article.
p130Cas is an essential transducer element in ErbB2 transformation.
Cabodi S, Tinnirello A, Bisaro B, Tornillo G, del Pilar Camacho-Leal M, Forni G, Cojoca R, Iezzi M, Amici A, Montani M, Eva A, Di Stefano P, Muthuswamy SK, Tarone G, Turco E, Defilippi P. Cabodi S, et al. Among authors: turco e. FASEB J. 2010 Oct;24(10):3796-808. doi: 10.1096/fj.10-157347. Epub 2010 May 26. FASEB J. 2010. PMID: 20505116
241 results