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Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans.
Sugiyama D, Nishikawa H, Maeda Y, Nishioka M, Tanemura A, Katayama I, Ezoe S, Kanakura Y, Sato E, Fukumori Y, Karbach J, Jäger E, Sakaguchi S. Sugiyama D, et al. Among authors: sakaguchi s. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17945-50. doi: 10.1073/pnas.1316796110. Epub 2013 Oct 14. Proc Natl Acad Sci U S A. 2013. PMID: 24127572 Free PMC article.
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody.
Ha D, Tanaka A, Kibayashi T, Tanemura A, Sugiyama D, Wing JB, Lim EL, Teng KWW, Adeegbe D, Newell EW, Katayama I, Nishikawa H, Sakaguchi S. Ha D, et al. Among authors: sakaguchi s. Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):609-618. doi: 10.1073/pnas.1812186116. Epub 2018 Dec 26. Proc Natl Acad Sci U S A. 2019. PMID: 30587582 Free PMC article.
Immunology. Damping by depletion.
Sakaguchi S, Wing K. Sakaguchi S, et al. Science. 2011 Apr 29;332(6029):542-3. doi: 10.1126/science.1206122. Science. 2011. PMID: 21527700 No abstract available.
CD8⁺ tumor-infiltrating lymphocytes at primary sites as a possible prognostic factor of cutaneous angiosarcoma.
Fujii H, Arakawa A, Utsumi D, Sumiyoshi S, Yamamoto Y, Kitoh A, Ono M, Matsumura Y, Kato M, Konishi K, Shiga T, Sano S, Sakaguchi S, Miyagawa-Hayashino A, Takahashi K, Uezato H, Miyachi Y, Tanioka M. Fujii H, et al. Among authors: sakaguchi s. Int J Cancer. 2014 May 15;134(10):2393-402. doi: 10.1002/ijc.28581. Epub 2013 Nov 18. Int J Cancer. 2014. PMID: 24243586 Free article.
Regulatory T Cells and Human Disease.
Sakaguchi S, Mikami N, Wing JB, Tanaka A, Ichiyama K, Ohkura N. Sakaguchi S, et al. Annu Rev Immunol. 2020 Apr 26;38:541-566. doi: 10.1146/annurev-immunol-042718-041717. Epub 2020 Feb 4. Annu Rev Immunol. 2020. PMID: 32017635 Review.
1,221 results