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Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy.
Havunen R, Siurala M, Sorsa S, Grönberg-Vähä-Koskela S, Behr M, Tähtinen S, Santos JM, Karell P, Rusanen J, Nettelbeck DM, Ehrhardt A, Kanerva A, Hemminki A. Havunen R, et al. Mol Ther Oncolytics. 2016 Dec 31;4:77-86. doi: 10.1016/j.omto.2016.12.004. eCollection 2017 Mar 17. Mol Ther Oncolytics. 2016. PMID: 28345026 Free PMC article.
Overcoming tumor resistance by heterologous adeno-poxvirus combination therapy.
Vähä-Koskela M, Tähtinen S, Grönberg-Vähä-Koskela S, Taipale K, Saha D, Merisalo-Soikkeli M, Ahonen M, Rouvinen-Lagerström N, Hirvinen M, Veckman V, Matikainen S, Zhao F, Pakarinen P, Salo J, Kanerva A, Cerullo V, Hemminki A. Vähä-Koskela M, et al. Mol Ther Oncolytics. 2015 Jan 7;1:14006. doi: 10.1038/mto.2014.6. eCollection 2015. Mol Ther Oncolytics. 2015. PMID: 27119097 Free PMC article.
Ad5/3 is able to avoid neutralization by binding to erythrocytes and lymphocytes.
Zafar S, Quixabeira DCA, Kudling TV, Cervera-Carrascon V, Santos JM, Grönberg-Vähä-Koskela S, Zhao F, Aronen P, Heiniö C, Havunen R, Sorsa S, Kanerva A, Hemminki A. Zafar S, et al. Cancer Gene Ther. 2021 May;28(5):442-454. doi: 10.1038/s41417-020-00226-z. Epub 2020 Sep 12. Cancer Gene Ther. 2021. PMID: 32920593 Free PMC article.
Local therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1.
Quixabeira DCA, Cervera-Carrascon V, Santos JM, Clubb JHA, Kudling TV, Basnet S, Heiniö C, Grönberg-Vähä-Koskela S, Anttila M, Havunen R, Kanerva A, Hemminki A. Quixabeira DCA, et al. Among authors: gronberg vaha koskela s. Oncoimmunology. 2022 Jan 22;11(1):2028960. doi: 10.1080/2162402X.2022.2028960. eCollection 2022. Oncoimmunology. 2022. PMID: 35083096 Free PMC article.
Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression.
Kudling TV, Clubb JHA, Quixabeira DCA, Santos JM, Havunen R, Kononov A, Heiniö C, Cervera-Carrascon V, Pakola S, Basnet S, Grönberg-Vähä-Koskela S, Arias V, Gladwyn-Ng I, Aro K, Bäck L, Räsänen J, Ilonen I, Borenius K, Räsänen M, Hemminki O, Rannikko A, Kanerva A, Tapper J, Hemminki A. Kudling TV, et al. Among authors: gronberg vaha koskela s. Oncoimmunology. 2022 Jul 12;11(1):2096572. doi: 10.1080/2162402X.2022.2096572. eCollection 2022. Oncoimmunology. 2022. PMID: 35845722 Free PMC article.
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