Hermone AR - Search Results

1

A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site.

Burnett JC, Lim C, Peyser BD, Samankumara LP, Kovaliov M, Colombo R, Bulfer SL, LaPorte MG, Hermone AR, McGrath CF, Arkin MR, Gussio R, Huryn DM, Wipf P. Burnett JC, et al. Among authors: hermone ar. Org Biomol Chem. 2017 May 16;15(19):4096-4114. doi: 10.1039/c7ob00526a. Org Biomol Chem. 2017. PMID: 28352916 Free PMC article.

2

Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.

Burnett JC, Schmidt JJ, McGrath CF, Nguyen TL, Hermone AR, Panchal RG, Vennerstrom JL, Kodukula K, Zaharevitz DW, Gussio R, Bavari S. Burnett JC, et al. Among authors: hermone ar. Bioorg Med Chem. 2005 Jan 17;13(2):333-41. doi: 10.1016/j.bmc.2004.10.026. Bioorg Med Chem. 2005. PMID: 15598556

3

Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining In Vivo Antitumor Efficacy.

Peyser BD, Hermone A, Salamoun JM, Burnett JC, Hollingshead MG, McGrath CF, Gussio R, Wipf P. Peyser BD, et al. Mol Cancer Ther. 2019 Oct;18(10):1765-1774. doi: 10.1158/1535-7163.MCT-19-0185. Epub 2019 Jul 24. Mol Cancer Ther. 2019. PMID: 31341033 Free PMC article.

4

A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach.

Nguyen TL, McGrath C, Hermone AR, Burnett JC, Zaharevitz DW, Day BW, Wipf P, Hamel E, Gussio R. Nguyen TL, et al. Among authors: hermone ar. J Med Chem. 2005 Sep 22;48(19):6107-16. doi: 10.1021/jm050502t. J Med Chem. 2005. PMID: 16162011

5

A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease.

Burnett JC, Opsenica D, Sriraghavan K, Panchal RG, Ruthel G, Hermone AR, Nguyen TL, Kenny TA, Lane DJ, McGrath CF, Schmidt JJ, Vennerstrom JL, Gussio R, Solaja BA, Bavari S. Burnett JC, et al. Among authors: hermone ar. J Med Chem. 2007 May 3;50(9):2127-36. doi: 10.1021/jm061446e. Epub 2007 Apr 7. J Med Chem. 2007. PMID: 17417831

6

Three-dimensional database mining identifies a unique chemotype that unites structurally diverse botulinum neurotoxin serotype A inhibitors in a three-zone pharmacophore.

Hermone AR, Burnett JC, Nuss JE, Tressler LE, Nguyen TL, Solaja BA, Vennerstrom JL, Schmidt JJ, Wipf P, Bavari S, Gussio R. Hermone AR, et al. ChemMedChem. 2008 Dec;3(12):1905-12. doi: 10.1002/cmdc.200800241. ChemMedChem. 2008. PMID: 19006141

7

Calculation methods for the enhancement of pharmaceutical properties in small molecules: estimating the cationic pKa.

Hermone AR, Gussio R. Hermone AR, et al. Curr Pharm Des. 2013;19(23):4310-5. doi: 10.2174/1381612811319230012. Curr Pharm Des. 2013. PMID: 23170887 Review.

8

Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.

Burnett JC, Ruthel G, Stegmann CM, Panchal RG, Nguyen TL, Hermone AR, Stafford RG, Lane DJ, Kenny TA, McGrath CF, Wipf P, Stahl AM, Schmidt JJ, Gussio R, Brunger AT, Bavari S. Burnett JC, et al. Among authors: hermone ar. J Biol Chem. 2007 Feb 16;282(7):5004-5014. doi: 10.1074/jbc.M608166200. Epub 2006 Nov 8. J Biol Chem. 2007. PMID: 17092934 Free article.

9

Pharmacophore-guided lead optimization: the rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease.

Burnett JC, Wang C, Nuss JE, Nguyen TL, Hermone AR, Schmidt JJ, Gussio R, Wipf P, Bavari S. Burnett JC, et al. Among authors: hermone ar. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5811-3. doi: 10.1016/j.bmcl.2009.01.111. Epub 2009 Feb 13. Bioorg Med Chem Lett. 2009. PMID: 19703771

10

Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.

Burnett JC, Schmidt JJ, Stafford RG, Panchal RG, Nguyen TL, Hermone AR, Vennerstrom JL, McGrath CF, Lane DJ, Sausville EA, Zaharevitz DW, Gussio R, Bavari S. Burnett JC, et al. Among authors: hermone ar. Biochem Biophys Res Commun. 2003 Oct 10;310(1):84-93. doi: 10.1016/j.bbrc.2003.08.112. Biochem Biophys Res Commun. 2003. PMID: 14511652

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