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23 results

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Page 1
Reassessing Phase II Heart Failure Clinical Trials: Consensus Recommendations.
Butler J, Hamo CE, Udelson JE, O'Connor C, Sabbah HN, Metra M, Shah SJ, Kitzman DW, Teerlink JR, Bernstein HS, Brooks G, Depre C, DeSouza MM, Dinh W, Donovan M, Frische-Danielson R, Frost RJ, Garza D, Gohring UM, Hellawell J, Hsia J, Ishihara S, Kay-Mugford P, Koglin J, Kozinn M, Larson CJ, Mayo M, Gan LM, Mugnier P, Mushonga S, Roessig L, Russo C, Salsali A, Satler C, Shi V, Ticho B, van der Laan M, Yancy C, Stockbridge N, Gheorghiade M. Butler J, et al. Among authors: frost rj. Circ Heart Fail. 2017 Apr;10(4):e003800. doi: 10.1161/CIRCHEARTFAILURE.116.003800. Circ Heart Fail. 2017. PMID: 28356300 Free PMC article.
First-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS-962212, a direct, reversible, small molecule factor XIa inhibitor in non-Japanese and Japanese healthy subjects.
Perera V, Luettgen JM, Wang Z, Frost CE, Yones C, Russo C, Lee J, Zhao Y, LaCreta FP, Ma X, Knabb RM, Seiffert D, DeSouza M, Mugnier P, Cirincione B, Ueno T, Frost RJA. Perera V, et al. Among authors: frost rja. Br J Clin Pharmacol. 2018 May;84(5):876-887. doi: 10.1111/bcp.13520. Epub 2018 Mar 5. Br J Clin Pharmacol. 2018. PMID: 29346838 Free PMC article. Clinical Trial.
A role for caspase-1 in heart failure.
Merkle S, Frantz S, Schön MP, Bauersachs J, Buitrago M, Frost RJ, Schmitteckert EM, Lohse MJ, Engelhardt S. Merkle S, et al. Among authors: frost rj. Circ Res. 2007 Mar 16;100(5):645-53. doi: 10.1161/01.RES.0000260203.55077.61. Epub 2007 Feb 15. Circ Res. 2007. PMID: 17303764
Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils.
Kirchgessner TG, Sleph P, Ostrowski J, Lupisella J, Ryan CS, Liu X, Fernando G, Grimm D, Shipkova P, Zhang R, Garcia R, Zhu J, He A, Malone H, Martin R, Behnia K, Wang Z, Barrett YC, Garmise RJ, Yuan L, Zhang J, Gandhi MD, Wastall P, Li T, Du S, Salvador L, Mohan R, Cantor GH, Kick E, Lee J, Frost RJ. Kirchgessner TG, et al. Among authors: frost rj. Cell Metab. 2016 Aug 9;24(2):223-33. doi: 10.1016/j.cmet.2016.07.016. Cell Metab. 2016. PMID: 27508871 Free article. Clinical Trial.
MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans.
Koch AW, Schiering N, Melkko S, Ewert S, Salter J, Zhang Y, McCormack P, Yu J, Huang X, Chiu YH, Chen Z, Schleeger S, Horny G, DiPetrillo K, Muller L, Hein A, Villard F, Scharenberg M, Ramage P, Hassiepen U, Côté S, DeGagne J, Krantz C, Eder J, Stoll B, Kulmatycki K, Feldman DL, Hoffmann P, Basson CT, Frost RJA, Khder Y. Koch AW, et al. Among authors: frost rja. Blood. 2019 Mar 28;133(13):1507-1516. doi: 10.1182/blood-2018-10-880849. Epub 2019 Jan 28. Blood. 2019. PMID: 30692123 Free article.
MicroRNAs add a new dimension to cardiovascular disease.
Small EM, Frost RJ, Olson EN. Small EM, et al. Among authors: frost rj. Circulation. 2010 Mar 2;121(8):1022-32. doi: 10.1161/CIRCULATIONAHA.109.889048. Circulation. 2010. PMID: 20194875 Free PMC article. Review. No abstract available.
23 results