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Next-Generation CDK2/9 Inhibitors and Anaphase Catastrophe in Lung Cancer.
Kawakami M, Mustachio LM, Rodriguez-Canales J, Mino B, Roszik J, Tong P, Wang J, Lee JJ, Myung JH, Heymach JV, Johnson FM, Hong S, Zheng L, Hu S, Villalobos PA, Behrens C, Wistuba I, Freemantle S, Liu X, Dmitrovsky E. Kawakami M, et al. Among authors: liu x. J Natl Cancer Inst. 2017 Jun 1;109(6):djw297. doi: 10.1093/jnci/djw297. J Natl Cancer Inst. 2017. PMID: 28376145 Free PMC article.
Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers.
Kawakami M, Mustachio LM, Zheng L, Chen Y, Rodriguez-Canales J, Mino B, Kurie JM, Roszik J, Villalobos PA, Thu KL, Silvester J, Cescon DW, Wistuba II, Mak TW, Liu X, Dmitrovsky E. Kawakami M, et al. Among authors: liu x. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1913-1918. doi: 10.1073/pnas.1719760115. Epub 2018 Feb 6. Proc Natl Acad Sci U S A. 2018. PMID: 29434041 Free PMC article.
New Cell Cycle Inhibitors Target Aneuploidy in Cancer Therapy.
Kawakami M, Liu X, Dmitrovsky E. Kawakami M, et al. Among authors: liu x. Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:361-377. doi: 10.1146/annurev-pharmtox-010818-021649. Epub 2018 Aug 15. Annu Rev Pharmacol Toxicol. 2019. PMID: 30110577 Review.
Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy.
Zheng L, Chen Z, Kawakami M, Chen Y, Roszik J, Mustachio LM, Kurie JM, Villalobos P, Lu W, Behrens C, Mino B, Solis LM, Silvester J, Thu KL, Cescon DW, Rodriguez-Canales J, Wistuba II, Mak TW, Liu X, Dmitrovsky E. Zheng L, et al. Among authors: liu x. Mol Cancer Ther. 2019 Oct;18(10):1775-1786. doi: 10.1158/1535-7163.MCT-18-0864. Epub 2019 Jul 29. Mol Cancer Ther. 2019. PMID: 31358662
A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers.
Kawakami M, Mustachio LM, Chen Y, Chen Z, Liu X, Wei CH, Roszik J, Kittai AS, Danilov AV, Zhang X, Fang B, Wang J, Heymach JV, Tyutyunyk-Massey L, Freemantle SJ, Kurie JM, Liu X, Dmitrovsky E. Kawakami M, et al. Among authors: liu x. Mol Cancer Ther. 2021 Mar;20(3):477-489. doi: 10.1158/1535-7163.MCT-19-0987. Epub 2020 Dec 4. Mol Cancer Ther. 2021. PMID: 33277443 Free PMC article.
Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis.
Chen Z, Zheng L, Chen Y, Liu X, Kawakami M, Mustachio LM, Roszik J, Ferry-Galow KV, Parchment RE, Liu X, Andresson T, Duncan G, Kurie JM, Rodriguez-Canales J, Liu X, Dmitrovsky E. Chen Z, et al. Among authors: liu x. Cancer Biol Ther. 2022 Dec 31;23(1):265-280. doi: 10.1080/15384047.2022.2054242. Cancer Biol Ther. 2022. PMID: 35387560 Free PMC article.
The ISG15-specific protease USP18 regulates stability of PTEN.
Mustachio LM, Kawakami M, Lu Y, Rodriguez-Canales J, Mino B, Behrens C, Wistuba I, Bota-Rabassedas N, Yu J, Lee JJ, Roszik J, Zheng L, Liu X, Freemantle SJ, Dmitrovsky E. Mustachio LM, et al. Among authors: liu x. Oncotarget. 2017 Jan 3;8(1):3-14. doi: 10.18632/oncotarget.13914. Oncotarget. 2017. PMID: 27980214 Free PMC article.
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