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Page 1
Advancements in the use of gene therapy for cardiac arrhythmia.
Murphy NP, Lubbers ER, Mohler PJ. Murphy NP, et al. Heart Rhythm. 2017 Jul;14(7):1061-1062. doi: 10.1016/j.hrthm.2017.03.041. Epub 2017 Apr 4. Heart Rhythm. 2017. PMID: 28385673 Free PMC article. No abstract available.
Molecular mechanisms underlying cardiac protein phosphatase 2A regulation in heart.
DeGrande ST, Little SC, Nixon DJ, Wright P, Snyder J, Dun W, Murphy N, Kilic A, Higgins R, Binkley PF, Boyden PA, Carnes CA, Anderson ME, Hund TJ, Mohler PJ. DeGrande ST, et al. J Biol Chem. 2013 Jan 11;288(2):1032-46. doi: 10.1074/jbc.M112.426957. Epub 2012 Nov 30. J Biol Chem. 2013. PMID: 23204520 Free PMC article.
SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia.
Musa H, Kline CF, Sturm AC, Murphy N, Adelman S, Wang C, Yan H, Johnson BL, Csepe TA, Kilic A, Higgins RS, Janssen PM, Fedorov VV, Weiss R, Salazar C, Hund TJ, Pitt GS, Mohler PJ. Musa H, et al. Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12528-33. doi: 10.1073/pnas.1516430112. Epub 2015 Sep 21. Proc Natl Acad Sci U S A. 2015. PMID: 26392562 Free PMC article.
Common human ANK2 variant confers in vivo arrhythmia phenotypes.
Musa H, Murphy NP, Curran J, Higgins JD, Webb TR, Makara MA, Wright P, Lancione PJ, Lubbers ER, Healy JA, Smith SA, Bennett V, Hund TJ, Kline CF, Mohler PJ. Musa H, et al. Among authors: murphy np. Heart Rhythm. 2016 Sep;13(9):1932-40. doi: 10.1016/j.hrthm.2016.06.012. Epub 2016 Jun 11. Heart Rhythm. 2016. PMID: 27298202
Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome.
Swayne LA, Murphy NP, Asuri S, Chen L, Xu X, McIntosh S, Wang C, Lancione PJ, Roberts JD, Kerr C, Sanatani S, Sherwin E, Kline CF, Zhang M, Mohler PJ, Arbour LT. Swayne LA, et al. Among authors: murphy np. Circ Cardiovasc Genet. 2017 Jan;10(1):e001537. doi: 10.1161/CIRCGENETICS.116.001537. Circ Cardiovasc Genet. 2017. PMID: 28196901 Free PMC article.
Novel Mechanistic Roles for Ankyrin-G in Cardiac Remodeling and Heart Failure.
Makara MA, Curran J, Lubbers ER, Murphy NP, Little SC, Musa H, Smith SA, Unudurthi SD, Rajaram MVS, Janssen PML, Boyden PA, Bradley EA, Hund TJ, Mohler PJ. Makara MA, et al. Among authors: murphy np. JACC Basic Transl Sci. 2018 Nov 12;3(5):675-689. doi: 10.1016/j.jacbts.2018.07.008. eCollection 2018 Oct. JACC Basic Transl Sci. 2018. PMID: 30456339 Free PMC article.
Protein Phosphatase 2A Regulates Cardiac Na+ Channels.
El Refaey M, Musa H, Murphy NP, Lubbers ER, Skaf M, Han M, Cavus O, Koenig SN, Wallace MJ, Gratz D, Bradley E, Alsina KM, Wehrens XHT, Hund TJ, Mohler PJ. El Refaey M, et al. Among authors: murphy np. Circ Res. 2019 Mar;124(5):737-746. doi: 10.1161/CIRCRESAHA.118.314350. Circ Res. 2019. PMID: 30602331 Free PMC article.
Defining new mechanistic roles for αII spectrin in cardiac function.
Lubbers ER, Murphy NP, Musa H, Huang CY, Gupta R, Price MV, Han M, Daoud E, Gratz D, El Refaey M, Xu X, Hoeflinger NK, Friel EL, Lancione P, Wallace MJ, Cavus O, Simmons SL, Williams JL, Skaf M, Koenig SN, Janssen PML, Rasband MN, Hund TJ, Mohler PJ. Lubbers ER, et al. Among authors: murphy np. J Biol Chem. 2019 Jun 14;294(24):9576-9591. doi: 10.1074/jbc.RA119.007714. Epub 2019 May 7. J Biol Chem. 2019. PMID: 31064843 Free PMC article.
Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy.
Roberts JD, Murphy NP, Hamilton RM, Lubbers ER, James CA, Kline CF, Gollob MH, Krahn AD, Sturm AC, Musa H, El-Refaey M, Koenig S, Aneq MÅ, Hoorntje ET, Graw SL, Davies RW, Rafiq MA, Koopmann TT, Aafaqi S, Fatah M, Chiasson DA, Taylor MR, Simmons SL, Han M, van Opbergen CJ, Wold LE, Sinagra G, Mittal K, Tichnell C, Murray B, Codima A, Nazer B, Nguyen DT, Marcus FI, Sobriera N, Lodder EM, van den Berg MP, Spears DA, Robinson JF, Ursell PC, Green AK, Skanes AC, Tang AS, Gardner MJ, Hegele RA, van Veen TA, Wilde AA, Healey JS, Janssen PM, Mestroni L, van Tintelen JP, Calkins H, Judge DP, Hund TJ, Scheinman MM, Mohler PJ. Roberts JD, et al. Among authors: murphy np. J Clin Invest. 2019 Jul 2;129(8):3171-3184. doi: 10.1172/JCI125538. eCollection 2019 Jul 2. J Clin Invest. 2019. PMID: 31264976 Free PMC article.
154 results