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Using available in vitro metabolite identification and time course kinetics for β-chloroprene and its metabolite, (1-chloroethenyl) oxirane, to include reactive oxidative metabolites and glutathione depletion in a PBPK model for β-chloroprene.
Campbell JL Jr, Clewell HJ 3rd, Van Landingham C, Gentry PR, Andersen ME. Campbell JL Jr, et al. Front Pharmacol. 2023 Aug 17;14:1223808. doi: 10.3389/fphar.2023.1223808. eCollection 2023. Front Pharmacol. 2023. PMID: 37663267 Free PMC article.
Integration of paraquat pharmacokinetic data across species using PBPK modelling.
Campbell JL Jr, Travis KZ, Clewell HJ 3rd, Stevens AJ, Hinderliter PM, Andersen ME, Botham PA, Cook AR, Minnema DJ, Wolf DC. Campbell JL Jr, et al. Toxicol Appl Pharmacol. 2021 Apr 15;417:115462. doi: 10.1016/j.taap.2021.115462. Epub 2021 Feb 22. Toxicol Appl Pharmacol. 2021. PMID: 33631233 Free article.
Paraquat pharmacokinetics in primates and extrapolation to humans.
Stevens AJ, Campbell JL Jr, Travis KZ, Clewell HJ 3rd, Hinderliter PM, Botham PA, Cook AR, Minnema DJ, Wolf DC. Stevens AJ, et al. Among authors: campbell jl jr. Toxicol Appl Pharmacol. 2021 Apr 15;417:115463. doi: 10.1016/j.taap.2021.115463. Epub 2021 Feb 22. Toxicol Appl Pharmacol. 2021. PMID: 33631232 Free article.
32 results