Bielser JM - Search Results

1

Modulation and modeling of monoclonal antibody N-linked glycosylation in mammalian cell perfusion reactors.

Karst DJ, Scibona E, Serra E, Bielser JM, Souquet J, Stettler M, Broly H, Soos M, Morbidelli M, Villiger TK. Karst DJ, et al. Among authors: bielser jm. Biotechnol Bioeng. 2017 Sep;114(9):1978-1990. doi: 10.1002/bit.26315. Epub 2017 May 23. Biotechnol Bioeng. 2017. PMID: 28409838

2

Screening and assessment of performance and molecule quality attributes of industrial cell lines across different fed-batch systems.

Rouiller Y, Bielser JM, Brühlmann D, Jordan M, Broly H, Stettler M. Rouiller Y, et al. Among authors: bielser jm. Biotechnol Prog. 2016 Jan-Feb;32(1):160-70. doi: 10.1002/btpr.2186. Epub 2015 Nov 3. Biotechnol Prog. 2016. PMID: 26489036

3

Robust factor selection in early cell culture process development for the production of a biosimilar monoclonal antibody.

Sokolov M, Ritscher J, MacKinnon N, Bielser JM, Brühlmann D, Rothenhäusler D, Thanei G, Soos M, Stettler M, Souquet J, Broly H, Morbidelli M, Butté A. Sokolov M, et al. Among authors: bielser jm. Biotechnol Prog. 2017 Jan;33(1):181-191. doi: 10.1002/btpr.2374. Epub 2016 Oct 31. Biotechnol Prog. 2017. PMID: 27689949

4

Perfusion mammalian cell culture for recombinant protein manufacturing - A critical review.

Bielser JM, Wolf M, Souquet J, Broly H, Morbidelli M. Bielser JM, et al. Biotechnol Adv. 2018 Jul-Aug;36(4):1328-1340. doi: 10.1016/j.biotechadv.2018.04.011. Epub 2018 May 5. Biotechnol Adv. 2018. PMID: 29738813 Free article. Review.

5

Improved Performance in Mammalian Cell Perfusion Cultures by Growth Inhibition.

Wolf MKF, Closet A, Bzowska M, Bielser JM, Souquet J, Broly H, Morbidelli M. Wolf MKF, et al. Among authors: bielser jm. Biotechnol J. 2019 Feb;14(2):e1700722. doi: 10.1002/biot.201700722. Epub 2018 Jun 4. Biotechnol J. 2019. PMID: 29781256

6

Semi-continuous scale-down models for clone and operating parameter screening in perfusion bioreactors.

Bielser JM, Domaradzki J, Souquet J, Broly H, Morbidelli M. Bielser JM, et al. Biotechnol Prog. 2019 May;35(3):e2790. doi: 10.1002/btpr.2790. Epub 2019 Mar 13. Biotechnol Prog. 2019. PMID: 30773840

7

Perfusion cell culture for the production of conjugated recombinant fusion proteins reduces clipping and quality heterogeneity compared to batch-mode processes.

Bielser JM, Chappuis L, Xiao Y, Souquet J, Broly H, Morbidelli M. Bielser JM, et al. J Biotechnol. 2019 Aug 20;302:26-31. doi: 10.1016/j.jbiotec.2019.06.006. Epub 2019 Jun 15. J Biotechnol. 2019. PMID: 31207262

8

Reduction of medium consumption in perfusion mammalian cell cultures using a perfusion rate equivalent concentrated nutrient feed.

Bielser JM, Kraus L, Burgos-Morales O, Broly H, Souquet J. Bielser JM, et al. Biotechnol Prog. 2020 Sep;36(5):e3026. doi: 10.1002/btpr.3026. Epub 2020 Jun 24. Biotechnol Prog. 2020. PMID: 32415806

9

Effects of pyruvate on primary metabolism and product quality for a high-density perfusion process.

Caso S, Aeby M, Jordan M, Guillot R, Bielser JM. Caso S, et al. Among authors: bielser jm. Biotechnol Bioeng. 2022 Apr;119(4):1053-1061. doi: 10.1002/bit.28033. Epub 2022 Jan 23. Biotechnol Bioeng. 2022. PMID: 35023143

10

Transfer of continuous manufacturing process principles for mAb production in a GMP environment: A step in the transition from batch to continuous.

Botelho Ferreira K, Benlegrimet A, Diane G, Pasquier V, Guillot R, De Poli M, Chappuis L, Vishwanathan N, Souquet J, Broly H, Bielser JM. Botelho Ferreira K, et al. Among authors: bielser jm. Biotechnol Prog. 2022 Jul;38(4):e3259. doi: 10.1002/btpr.3259. Epub 2022 Apr 26. Biotechnol Prog. 2022. PMID: 35412696

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