Yang CY - Search Results

1

Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor.

Zhao Y, Bai L, Liu L, McEachern D, Stuckey JA, Meagher JL, Yang CY, Ran X, Zhou B, Hu Y, Li X, Wen B, Zhao T, Li S, Sun D, Wang S. Zhao Y, et al. Among authors: yang cy. J Med Chem. 2017 May 11;60(9):3887-3901. doi: 10.1021/acs.jmedchem.7b00193. Epub 2017 May 2. J Med Chem. 2017. PMID: 28463487 Free PMC article.

2

Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.

Sun H, Nikolovska-Coleska Z, Yang CY, Xu L, Tomita Y, Krajewski K, Roller PP, Wang S. Sun H, et al. Among authors: yang cy. J Med Chem. 2004 Aug 12;47(17):4147-50. doi: 10.1021/jm0499108. J Med Chem. 2004. PMID: 15293984

3

Structure-based discovery of nonpeptidic small organic compounds to block the T cell response to myelin basic protein.

Koehler NK, Yang CY, Varady J, Lu Y, Wu XW, Liu M, Yin D, Bartels M, Xu BY, Roller PP, Long YQ, Li P, Kattah M, Cohn ML, Moran K, Tilley E, Richert JR, Wang S. Koehler NK, et al. Among authors: yang cy. J Med Chem. 2004 Oct 7;47(21):4989-97. doi: 10.1021/jm030362s. J Med Chem. 2004. PMID: 15456243

4

Structure-based design of potent, conformationally constrained Smac mimetics.

Sun H, Nikolovska-Coleska Z, Yang CY, Xu L, Liu M, Tomita Y, Pan H, Yoshioka Y, Krajewski K, Roller PP, Wang S. Sun H, et al. Among authors: yang cy. J Am Chem Soc. 2004 Dec 29;126(51):16686-7. doi: 10.1021/ja047438+. J Am Chem Soc. 2004. PMID: 15612682

5

Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.

Sun H, Nikolovska-Coleska Z, Chen J, Yang CY, Tomita Y, Pan H, Yoshioka Y, Krajewski K, Roller PP, Wang S. Sun H, et al. Among authors: yang cy. Bioorg Med Chem Lett. 2005 Feb 1;15(3):793-7. doi: 10.1016/j.bmcl.2004.11.008. Bioorg Med Chem Lett. 2005. PMID: 15664859

6

Enantiomerically pure hexahydropyrazinoquinolines as potent and selective dopamine 3 subtype receptor ligands.

Ding K, Chen J, Ji M, Wu X, Varady J, Yang CY, Lu Y, Deschamps JR, Levant B, Wang S. Ding K, et al. Among authors: yang cy. J Med Chem. 2005 May 5;48(9):3171-81. doi: 10.1021/jm049031l. J Med Chem. 2005. PMID: 15857123

7

The PDBbind database: methodologies and updates.

Wang R, Fang X, Lu Y, Yang CY, Wang S. Wang R, et al. Among authors: yang cy. J Med Chem. 2005 Jun 16;48(12):4111-9. doi: 10.1021/jm048957q. J Med Chem. 2005. PMID: 15943484

8

A systematic analysis of the effect of small-molecule binding on protein flexibility of the ligand-binding sites.

Yang CY, Wang R, Wang S. Yang CY, et al. J Med Chem. 2005 Sep 8;48(18):5648-50. doi: 10.1021/jm050276n. J Med Chem. 2005. PMID: 16134931

9

Binding free energy contributions of interfacial waters in HIV-1 protease/inhibitor complexes.

Lu Y, Yang CY, Wang S. Lu Y, et al. Among authors: yang cy. J Am Chem Soc. 2006 Sep 13;128(36):11830-9. doi: 10.1021/ja058042g. J Am Chem Soc. 2006. PMID: 16953623

10

M-score: a knowledge-based potential scoring function accounting for protein atom mobility.

Yang CY, Wang R, Wang S. Yang CY, et al. J Med Chem. 2006 Oct 5;49(20):5903-11. doi: 10.1021/jm050043w. J Med Chem. 2006. PMID: 17004706

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