Khuri FR - Search Results

1

HMG-CoA synthase 1 is a synthetic lethal partner of BRAF^V600E in human cancers.

Zhao L, Fan J, Xia S, Pan Y, Liu S, Qian G, Qian Z, Kang HB, Arbiser JL, Pollack BP, Kudchadkar RR, Lawson DH, Rossi M, Abdel-Wahab O, Merghoub T, Khoury HJ, Khuri FR, Boise LH, Lonial S, Chen F, Chen J, Lin R. Zhao L, et al. Among authors: khuri fr. J Biol Chem. 2017 Jun 16;292(24):10142-10152. doi: 10.1074/jbc.M117.788778. Epub 2017 May 3. J Biol Chem. 2017. PMID: 28468827 Free PMC article.

2

The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT.

David E, Sun SY, Waller EK, Chen J, Khuri FR, Lonial S. David E, et al. Among authors: khuri fr. Blood. 2005 Dec 15;106(13):4322-9. doi: 10.1182/blood-2005-06-2584. Epub 2005 Aug 23. Blood. 2005. PMID: 16118318 Free article.

3

14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells.

Dong S, Kang S, Gu TL, Kardar S, Fu H, Lonial S, Khoury HJ, Khuri F, Chen J. Dong S, et al. Blood. 2007 Jul 1;110(1):360-9. doi: 10.1182/blood-2006-12-065615. Epub 2007 Mar 27. Blood. 2007. PMID: 17389761 Free PMC article.

4

The farnesyltransferase inhibitor lonafarnib induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells.

Sun SY, Liu X, Zou W, Yue P, Marcus AI, Khuri FR. Sun SY, et al. Among authors: khuri fr. J Biol Chem. 2007 Jun 29;282(26):18800-9. doi: 10.1074/jbc.M611438200. Epub 2007 May 9. J Biol Chem. 2007. PMID: 17493934 Free article.

5

The farnesyltransferase inhibitor R115777 up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer cells.

Qiu Y, Liu X, Zou W, Yue P, Lonial S, Khuri FR, Sun SY. Qiu Y, et al. Among authors: khuri fr. Cancer Res. 2007 May 15;67(10):4973-80. doi: 10.1158/0008-5472.CAN-06-4044. Cancer Res. 2007. PMID: 17510428

6

The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells.

Liu X, Yue P, Chen S, Hu L, Lonial S, Khuri FR, Sun SY. Liu X, et al. Among authors: khuri fr. Cancer Res. 2007 May 15;67(10):4981-8. doi: 10.1158/0008-5472.CAN-06-4274. Cancer Res. 2007. PMID: 17510429

7

The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway.

Elrod HA, Lin YD, Yue P, Wang X, Lonial S, Khuri FR, Sun SY. Elrod HA, et al. Among authors: khuri fr. Mol Cancer Ther. 2007 Jul;6(7):2029-38. doi: 10.1158/1535-7163.MCT-07-0004. Epub 2007 Jun 29. Mol Cancer Ther. 2007. PMID: 17604333

8

The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.

Raja SM, Chen S, Yue P, Acker TM, Lefkove B, Arbiser JL, Khuri FR, Sun SY. Raja SM, et al. Among authors: khuri fr. Mol Cancer Ther. 2008 Jul;7(7):2212-23. doi: 10.1158/1535-7163.MCT-07-2409. Mol Cancer Ther. 2008. PMID: 18645030 Free PMC article.

9

The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner.

Zhou J, Vos CC, Gjyrezi A, Yoshida M, Khuri FR, Tamanoi F, Giannakakou P. Zhou J, et al. Among authors: khuri fr. J Biol Chem. 2009 Apr 10;284(15):9648-55. doi: 10.1074/jbc.M808708200. Epub 2009 Feb 18. J Biol Chem. 2009. PMID: 19228685 Free PMC article.

10

The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R.

Zhong D, Xiong L, Liu T, Liu X, Liu X, Chen J, Sun SY, Khuri FR, Zong Y, Zhou Q, Zhou W. Zhong D, et al. Among authors: khuri fr. J Biol Chem. 2009 Aug 28;284(35):23225-33. doi: 10.1074/jbc.M109.005280. Epub 2009 Jul 1. J Biol Chem. 2009. PMID: 19574224 Free PMC article.

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