Thean D - Search Results

1

Enhancing Specific Disruption of Intracellular Protein Complexes by Hydrocarbon Stapled Peptides Using Lipid Based Delivery.

Thean D, Ebo JS, Luxton T, Lee XC, Yuen TY, Ferrer FJ, Johannes CW, Lane DP, Brown CJ. Thean D, et al. Sci Rep. 2017 May 11;7(1):1763. doi: 10.1038/s41598-017-01712-5. Sci Rep. 2017. PMID: 28496125 Free PMC article.

2

Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids.

Chee SMQ, Wongsantichon J, Siau J, Thean D, Ferrer F, Robinson RC, Lane DP, Brown CJ, Ghadessy FJ. Chee SMQ, et al. Among authors: thean d. PLoS One. 2017 Dec 11;12(12):e0189379. doi: 10.1371/journal.pone.0189379. eCollection 2017. PLoS One. 2017. PMID: 29228061 Free PMC article.

3

Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties.

Partridge AW, Kaan HYK, Juang YC, Sadruddin A, Lim S, Brown CJ, Ng S, Thean D, Ferrer F, Johannes C, Yuen TY, Kannan S, Aronica P, Tan YS, Pradhan MR, Verma CS, Hochman J, Chen S, Wan H, Ha S, Sherborne B, Lane DP, Sawyer TK. Partridge AW, et al. Among authors: thean d. Molecules. 2019 Jun 20;24(12):2292. doi: 10.3390/molecules24122292. Molecules. 2019. PMID: 31226791 Free PMC article.

4

Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles.

Yuen TY, Brown CJ, Xue Y, Tan YS, Ferrer Gago FJ, Lee XE, Neo JY, Thean D, Kaan HYK, Partridge AW, Verma CS, Lane DP, Johannes CW. Yuen TY, et al. Among authors: thean d. Chem Sci. 2019 May 30;10(26):6457-6466. doi: 10.1039/c9sc01456j. eCollection 2019 Jul 14. Chem Sci. 2019. PMID: 31316744 Free PMC article.

5

Rigorous Computational and Experimental Investigations on MDM2/MDMX-Targeted Linear and Macrocyclic Peptides.

Diller DJ, Swanson J, Bayden AS, Brown CJ, Thean D, Lane DP, Partridge AW, Sawyer TK, Audie J. Diller DJ, et al. Among authors: thean d. Molecules. 2019 Dec 14;24(24):4586. doi: 10.3390/molecules24244586. Molecules. 2019. PMID: 31847417 Free PMC article.

6

Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides.

Desai TJ, Habulihaz B, Cannon JR, Chandramohan A, Kaan HYK, Sadruddin A, Yuen TY, Johannes C, Thean D, Brown CJ, Lane DP, Partridge AW, Evers R, Sawyer TK, Hochman J. Desai TJ, et al. Among authors: thean d. Pharm Res. 2021 May;38(5):843-850. doi: 10.1007/s11095-021-03005-z. Epub 2021 Mar 15. Pharm Res. 2021. PMID: 33723794

7

NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay.

Peier A, Ge L, Boyer N, Frost J, Duggal R, Biswas K, Edmondson S, Hermes JD, Yan L, Zimprich C, Sadruddin A, Kristal Kaan HY, Chandramohan A, Brown CJ, Thean D, Lee XE, Yuen TY, Ferrer-Gago FJ, Johannes CW, Lane DP, Sherborne B, Corona C, Robers MB, Sawyer TK, Partridge AW. Peier A, et al. Among authors: thean d. ACS Chem Biol. 2021 Feb 19;16(2):293-309. doi: 10.1021/acschembio.0c00804. Epub 2021 Feb 4. ACS Chem Biol. 2021. PMID: 33539064

8

Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design.

Tan YS, Reeks J, Brown CJ, Thean D, Ferrer Gago FJ, Yuen TY, Goh ET, Lee XE, Jennings CE, Joseph TL, Lakshminarayanan R, Lane DP, Noble ME, Verma CS. Tan YS, et al. Among authors: thean d. J Phys Chem Lett. 2016 Sep 1;7(17):3452-7. doi: 10.1021/acs.jpclett.6b01525. Epub 2016 Aug 22. J Phys Chem Lett. 2016. PMID: 27532490 Free PMC article.

9

Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex.

Frosi Y, Lin YC, Shimin J, Ramlan SR, Hew K, Engman AH, Pillai A, Yeung K, Cheng YX, Cornvik T, Nordlund P, Goh M, Lama D, Gates ZP, Verma CS, Thean D, Lane DP, Asial I, Brown CJ. Frosi Y, et al. Among authors: thean d. Nat Commun. 2022 Aug 18;13(1):4854. doi: 10.1038/s41467-022-32463-1. Nat Commun. 2022. PMID: 35982046 Free PMC article.

10

Correction to: Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides.

Desai TJ, Habulihaz B, Cannon JR, Chandramohan A, Kaan HYK, Sadruddin A, Yuen TY, Johannes C, Thean D, Brown CJ, Lane DP, Partridge AW, Evers R, Sawyer TK, Hochman J. Desai TJ, et al. Among authors: thean d. Pharm Res. 2021 Apr;38(4):735-736. doi: 10.1007/s11095-021-03033-9. Pharm Res. 2021. PMID: 33821425 No abstract available.

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