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Biological Characterization of AB-343, a Novel and Potent SARS-CoV-2 Mpro Inhibitor with Pan-Coronavirus Activity.
McGovern-Gooch KR, Mani N, Gotchev D, Ardzinski A, Kowalski R, Sheraz M, Micolochick Steuer HM, Tercero B, Wang X, Wasserman A, Chen CY, von König K, Maskos K, Prasad A, Blaesse M, Bergmann A, Konz Makino DL, Fan KY, Kultgen SG, Lindstrom A, Nguyen D, Vega M, Wang X, Bracci N, Weiss SR, Cole AG, Lam AM, Cuconati A, Sofia MJ. McGovern-Gooch KR, et al. Among authors: lam am. Antiviral Res. 2024 Nov 20:106038. doi: 10.1016/j.antiviral.2024.106038. Online ahead of print. Antiviral Res. 2024. PMID: 39577571
CarersCanADAPT: Study protocol of a stepped care pathway and hybrid type 1 effectiveness-implementation trial of an online cognitive behavioural therapy (iCBT) program for cancer carers with anxiety and depression.
Laidsaar-Powell R, Giunta S, Beatty L, Butow P, Costa D, Lam A, Juraskova I, Cook O, Crawford-Williams F, Rankin NM, Shaw J. Laidsaar-Powell R, et al. Among authors: lam a. Contemp Clin Trials. 2024 Nov 17:107749. doi: 10.1016/j.cct.2024.107749. Online ahead of print. Contemp Clin Trials. 2024. PMID: 39561919 Free article.
A randomized, placebo-controlled first-in-human study of oral TQS-168 in healthy volunteers: Assessment of safety, tolerability, pharmacokinetics, pharmacodynamics, and food effect.
Hannestad J, Smith S, Lam A, Hurt J, Harada N, Kim R, Das A, Brunello J, Whitaker G, Chalmers D, Senjoti F, Lin W, Coghill J, Bansal Y, Sidhu S, Zann V, Liu E. Hannestad J, et al. Among authors: lam a. Clin Transl Sci. 2024 Nov;17(11):e70064. doi: 10.1111/cts.70064. Clin Transl Sci. 2024. PMID: 39535924 Free PMC article. Clinical Trial.
Structure-Activity Relationships and Discovery of (S)-5-(tert-Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido[2',1':2,3]imidazo[4,5-h]quinoline-3-carboxylic Acid (AB-161), a Novel Orally Available and Liver-Centric HBV RNA Destabilizer.
Gotchev D, Chen S, Dugan B, Dorsey BD, Wang X, Sheraz M, Kowalski R, Liu F, Tang S, Chiu T, Harasym T, Graves IE, Thi EP, Mason JD, Overholt N, Dugyala R, Lam AM, Cole AG, Sofia MJ. Gotchev D, et al. Among authors: lam am. J Med Chem. 2024 Nov 8. doi: 10.1021/acs.jmedchem.4c01928. Online ahead of print. J Med Chem. 2024. PMID: 39513566
2,266 results