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Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy.
Taylor AB, Roberts KM, Cao X, Clark NE, Holloway SP, Donati E, Polcaro CM, Pica-Mattoccia L, Tarpley RS, McHardy SF, Cioli D, LoVerde PT, Fitzpatrick PF, Hart PJ. Taylor AB, et al. Among authors: mchardy sf. J Biol Chem. 2017 Jul 7;292(27):11154-11164. doi: 10.1074/jbc.M116.766527. Epub 2017 May 23. J Biol Chem. 2017. PMID: 28536265 Free PMC article.
Molecular basis for hycanthone drug action in schistosome parasites.
Guzman M, Rugel A, Tarpley RS, Cao X, McHardy SF, LoVerde PT, Taylor AB. Guzman M, et al. Among authors: mchardy sf. Mol Biochem Parasitol. 2020 Mar;236:111257. doi: 10.1016/j.molbiopara.2020.111257. Epub 2020 Feb 3. Mol Biochem Parasitol. 2020. PMID: 32027942
Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?
Rugel AR, Guzman MA, Taylor AB, Chevalier FD, Tarpley RS, McHardy SF, Cao X, Holloway SP, Anderson TJC, Hart PJ, LoVerde PT. Rugel AR, et al. Among authors: mchardy sf. Int J Parasitol Drugs Drug Resist. 2020 Aug;13:8-15. doi: 10.1016/j.ijpddr.2020.04.001. Epub 2020 Apr 10. Int J Parasitol Drugs Drug Resist. 2020. PMID: 32315953 Free PMC article.
An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans.
Guzman MA, Rugel AR, Tarpley RS, Alwan SN, Chevalier FD, Kovalskyy DP, Cao X, Holloway SP, Anderson TJC, Taylor AB, McHardy SF, LoVerde PT. Guzman MA, et al. Among authors: mchardy sf. PLoS Negl Trop Dis. 2020 Aug 18;14(8):e0008517. doi: 10.1371/journal.pntd.0008517. eCollection 2020 Aug. PLoS Negl Trop Dis. 2020. PMID: 32810153 Free PMC article.
Rational approach to drug discovery for human schistosomiasis.
LoVerde PT, Alwan SN, Taylor AB, Rhodes J, Chevalier FD, Anderson TJ, McHardy SF. LoVerde PT, et al. Among authors: mchardy sf. Int J Parasitol Drugs Drug Resist. 2021 Aug;16:140-147. doi: 10.1016/j.ijpddr.2021.05.002. Epub 2021 Jun 4. Int J Parasitol Drugs Drug Resist. 2021. PMID: 34111649 Free PMC article. Review.
Corrigendum to "Rational approach to drug discovery for human schistosomiasis" [Int. J. Parasitol. Drugs Drug Resist. 16 (2021) 140-147].
LoVerde PT, Alwan SN, Taylor AB, Rhodes J, Chevalier FD, Anderson TJ, McHardy SF. LoVerde PT, et al. Among authors: mchardy sf. Int J Parasitol Drugs Drug Resist. 2022 Apr;18:103. doi: 10.1016/j.ijpddr.2022.01.003. Epub 2022 Jan 19. Int J Parasitol Drugs Drug Resist. 2022. PMID: 35067439 Free PMC article. No abstract available.
Schistosome Sulfotransferases: Mode of Action, Expression and Localization.
Guzman MA, Rugel A, Alwan SN, Tarpley R, Taylor AB, Chevalier FD, Wendt GR, Collins JJ 3rd, Anderson TJC, McHardy SF, LoVerde PT. Guzman MA, et al. Among authors: mchardy sf. Pharmaceutics. 2022 Jul 6;14(7):1416. doi: 10.3390/pharmaceutics14071416. Pharmaceutics. 2022. PMID: 35890311 Free PMC article.
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