Church RJ - Search Results

1

Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072.

Paech F, Messner S, Spickermann J, Wind M, Schmitt-Hoffmann AH, Witschi AT, Howell BA, Church RJ, Woodhead J, Engelhardt M, Krähenbühl S, Maurer M. Paech F, et al. Among authors: church rj. Arch Toxicol. 2017 Nov;91(11):3647-3662. doi: 10.1007/s00204-017-1994-x. Epub 2017 May 23. Arch Toxicol. 2017. PMID: 28536862 Clinical Trial.

2

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.

Woodhead JL, Brock WJ, Roth SE, Shoaf SE, Brouwer KL, Church R, Grammatopoulos TN, Stiles L, Siler SQ, Howell BA, Mosedale M, Watkins PB, Shoda LK. Woodhead JL, et al. Toxicol Sci. 2017 Jan;155(1):61-74. doi: 10.1093/toxsci/kfw193. Epub 2016 Sep 21. Toxicol Sci. 2017. PMID: 27655350 Free PMC article.

3

Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury.

Holman NS, Church RJ, Nautiyal M, Rose KA, Thacker SE, Otieno MA, Wolf KK, LeCluyse E, Watkins PB, Mosedale M. Holman NS, et al. Among authors: church rj. Toxicol Sci. 2019 Aug 1;170(2):499-508. doi: 10.1093/toxsci/kfz112. Toxicol Sci. 2019. PMID: 31093666 Free PMC article.

4

Glutamate dehydrogenase as a biomarker for mitotoxicity; insights from furosemide hepatotoxicity in the mouse.

Church RJ, Schomaker SJ, Eaddy JS, Boucher GG, Kreeger JM, Aubrecht J, Watkins PB. Church RJ, et al. PLoS One. 2020 Oct 9;15(10):e0240562. doi: 10.1371/journal.pone.0240562. eCollection 2020. PLoS One. 2020. PMID: 33035276 Free PMC article.

5

Beyond miR-122: Identification of MicroRNA Alterations in Blood During a Time Course of Hepatobiliary Injury and Biliary Hyperplasia in Rats.

Church RJ, Otieno M, McDuffie JE, Singh B, Sonee M, Hall L, Watkins PB, Ellinger-Ziegelbauer H, Harrill AH. Church RJ, et al. Toxicol Sci. 2016 Mar;150(1):3-14. doi: 10.1093/toxsci/kfv260. Epub 2015 Nov 26. Toxicol Sci. 2016. PMID: 26614776 Free PMC article.

6

Serum biomarkers of drug-induced liver injury: Current status and future directions.

Church RJ, Watkins PB. Church RJ, et al. J Dig Dis. 2019 Jan;20(1):2-10. doi: 10.1111/1751-2980.12684. Epub 2018 Dec 5. J Dig Dis. 2019. PMID: 30378260 Review.

7

In silico modeling to optimize interpretation of liver safety biomarkers in clinical trials.

Church RJ, Watkins PB. Church RJ, et al. Exp Biol Med (Maywood). 2018 Feb;243(3):300-307. doi: 10.1177/1535370217740853. Epub 2017 Nov 2. Exp Biol Med (Maywood). 2018. PMID: 29096561 Free PMC article. Review.

8

The transformation in biomarker detection and management of drug-induced liver injury.

Church RJ, Watkins PB. Church RJ, et al. Liver Int. 2017 Nov;37(11):1582-1590. doi: 10.1111/liv.13441. Epub 2017 May 8. Liver Int. 2017. PMID: 28386997 Free PMC article. Review.

9

A systems biology approach utilizing a mouse diversity panel identifies genetic differences influencing isoniazid-induced microvesicular steatosis.

Church RJ, Wu H, Mosedale M, Sumner SJ, Pathmasiri W, Kurtz CL, Pletcher MT, Eaddy JS, Pandher K, Singer M, Batheja A, Watkins PB, Adkins K, Harrill AH. Church RJ, et al. Toxicol Sci. 2014 Aug 1;140(2):481-92. doi: 10.1093/toxsci/kfu094. Epub 2014 May 20. Toxicol Sci. 2014. PMID: 24848797 Free PMC article.

10

Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice.

Church RJ, Gatti DM, Urban TJ, Long N, Yang X, Shi Q, Eaddy JS, Mosedale M, Ballard S, Churchill GA, Navarro V, Watkins PB, Threadgill DW, Harrill AH. Church RJ, et al. Food Chem Toxicol. 2015 Feb;76:19-26. doi: 10.1016/j.fct.2014.11.008. Epub 2014 Nov 28. Food Chem Toxicol. 2015. PMID: 25446466 Free PMC article.

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