Paech F - Search Results

1

Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072.

Paech F, Messner S, Spickermann J, Wind M, Schmitt-Hoffmann AH, Witschi AT, Howell BA, Church RJ, Woodhead J, Engelhardt M, Krähenbühl S, Maurer M. Paech F, et al. Arch Toxicol. 2017 Nov;91(11):3647-3662. doi: 10.1007/s00204-017-1994-x. Epub 2017 May 23. Arch Toxicol. 2017. PMID: 28536862 Clinical Trial.

2

Mechanisms of toxicity associated with six tyrosine kinase inhibitors in human hepatocyte cell lines.

Mingard C, Paech F, Bouitbir J, Krähenbühl S. Mingard C, et al. Among authors: paech f. J Appl Toxicol. 2018 Mar;38(3):418-431. doi: 10.1002/jat.3551. Epub 2017 Oct 26. J Appl Toxicol. 2018. PMID: 29072336

3

Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice.

Paech F, Abegg VF, Duthaler U, Terracciano L, Bouitbir J, Krähenbühl S. Paech F, et al. Toxicology. 2018 Nov 1;409:13-23. doi: 10.1016/j.tox.2018.07.009. Epub 2018 Jul 18. Toxicology. 2018. PMID: 30031043

4

Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis.

Paech F, Bouitbir J, Krähenbühl S. Paech F, et al. Front Pharmacol. 2017 Jun 14;8:367. doi: 10.3389/fphar.2017.00367. eCollection 2017. Front Pharmacol. 2017. PMID: 28659801 Free PMC article.

5

Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells.

Paech F, Mingard C, Grünig D, Abegg VF, Bouitbir J, Krähenbühl S. Paech F, et al. Toxicology. 2018 Feb 15;395:34-44. doi: 10.1016/j.tox.2018.01.005. Epub 2018 Jan 16. Toxicology. 2018. PMID: 29341879

6

Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling.

Woodhead JL, Paech F, Maurer M, Engelhardt M, Schmitt-Hoffmann AH, Spickermann J, Messner S, Wind M, Witschi AT, Krähenbühl S, Siler SQ, Watkins PB, Howell BA. Woodhead JL, et al. Among authors: paech f. Clin Transl Sci. 2018 Sep;11(5):498-505. doi: 10.1111/cts.12560. Epub 2018 Jun 7. Clin Transl Sci. 2018. PMID: 29877622 Free PMC article.

7

Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib: Running title: Sunitinib and oxidative stress in hearts.

Bouitbir J, Alshaikhali A, Panajatovic MV, Abegg VF, Paech F, Krähenbühl S. Bouitbir J, et al. Among authors: paech f. Toxicology. 2019 Oct 1;426:152281. doi: 10.1016/j.tox.2019.152281. Epub 2019 Aug 22. Toxicology. 2019. PMID: 31445075

8

Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin.

Brecht K, Riebel V, Couttet P, Paech F, Wolf A, Chibout SD, Pognan F, Krähenbühl S, Uteng M. Brecht K, et al. Among authors: paech f. Toxicol In Vitro. 2017 Apr;40:55-65. doi: 10.1016/j.tiv.2016.12.001. Epub 2016 Dec 5. Toxicol In Vitro. 2017. PMID: 27923774

9

Mechanisms of Cardiotoxicity Associated with Tyrosine Kinase Inhibitors in H9c2 Cells and Mice.

Bouitbir J, Alshaikhali A, Panajatovic M, Abegg V, Paech F, Krähenbühl S. Bouitbir J, et al. Among authors: paech f. Eur Cardiol. 2020 May 15;15:e33. doi: 10.15420/ecr.2020.15.1.PO10. eCollection 2020 Feb. Eur Cardiol. 2020. PMID: 32612693 Free PMC article. Review. No abstract available.

10

Induction of mitophagy in the HEI-OC1 auditory cell line and activation of the Atg12/LC3 pathway in the organ of Corti.

Setz C, Benischke AS, Pinho Ferreira Bento AC, Brand Y, Levano S, Paech F, Leitmeyer K, Bodmer D. Setz C, et al. Among authors: paech f. Hear Res. 2018 Apr;361:52-65. doi: 10.1016/j.heares.2018.01.003. Epub 2018 Jan 11. Hear Res. 2018. PMID: 29352609

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