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Page 1
TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms.
Chao YK, Schludi V, Chen CC, Butz E, Nguyen ONP, Müller M, Krüger J, Kammerbauer C, Ben-Johny M, Vollmar AM, Berking C, Biel M, Wahl-Schott CA, Grimm C. Chao YK, et al. Among authors: nguyen onp. Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8595-E8602. doi: 10.1073/pnas.1705739114. Epub 2017 Sep 18. Proc Natl Acad Sci U S A. 2017. PMID: 28923947 Free PMC article.
Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth.
Müller M, Gerndt S, Chao YK, Zisis T, Nguyen ONP, Gerwien A, Urban N, Müller C, Gegenfurtner FA, Geisslinger F, Ortler C, Chen CC, Zahler S, Biel M, Schaefer M, Grimm C, Bracher F, Vollmar AM, Bartel K. Müller M, et al. Among authors: nguyen onp. Cell Chem Biol. 2021 Aug 19;28(8):1119-1131.e27. doi: 10.1016/j.chembiol.2021.01.023. Epub 2021 Feb 23. Cell Chem Biol. 2021. PMID: 33626324 Free article.
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.
Gerndt S, Chen CC, Chao YK, Yuan Y, Burgstaller S, Scotto Rosato A, Krogsaeter E, Urban N, Jacob K, Nguyen ONP, Miller MT, Keller M, Vollmar AM, Gudermann T, Zierler S, Schredelseker J, Schaefer M, Biel M, Malli R, Wahl-Schott C, Bracher F, Patel S, Grimm C. Gerndt S, et al. Among authors: nguyen onp. Elife. 2020 Mar 16;9:e54712. doi: 10.7554/eLife.54712. Elife. 2020. PMID: 32167471 Free PMC article.