Thomas PJ - Search Results

1

Direct Binding of the Corrector VX-809 to Human CFTR NBD1: Evidence of an Allosteric Coupling between the Binding Site and the NBD1:CL4 Interface.

Hudson RP, Dawson JE, Chong PA, Yang Z, Millen L, Thomas PJ, Brouillette CG, Forman-Kay JD. Hudson RP, et al. Among authors: thomas pj. Mol Pharmacol. 2017 Aug;92(2):124-135. doi: 10.1124/mol.117.108373. Epub 2017 May 25. Mol Pharmacol. 2017. PMID: 28546419

2

Alteration of the cystic fibrosis transmembrane conductance regulator folding pathway.

Qu BH, Thomas PJ. Qu BH, et al. Among authors: thomas pj. J Biol Chem. 1996 Mar 29;271(13):7261-4. doi: 10.1074/jbc.271.13.7261. J Biol Chem. 1996. PMID: 8631737 Free article.

3

Localization and suppression of a kinetic defect in cystic fibrosis transmembrane conductance regulator folding.

Qu BH, Strickland EH, Thomas PJ. Qu BH, et al. Among authors: thomas pj. J Biol Chem. 1997 Jun 20;272(25):15739-44. doi: 10.1074/jbc.272.25.15739. J Biol Chem. 1997. PMID: 9188468 Free article.

4

The molecular chaperone Hsc70 assists the in vitro folding of the N-terminal nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator.

Strickland E, Qu BH, Millen L, Thomas PJ. Strickland E, et al. Among authors: thomas pj. J Biol Chem. 1997 Oct 10;272(41):25421-4. doi: 10.1074/jbc.272.41.25421. J Biol Chem. 1997. PMID: 9325249 Free article.

5

Cystic fibrosis: a disease of altered protein folding.

Qu BH, Strickland E, Thomas PJ. Qu BH, et al. Among authors: thomas pj. J Bioenerg Biomembr. 1997 Oct;29(5):483-90. doi: 10.1023/a:1022439108101. J Bioenerg Biomembr. 1997. PMID: 9511933 Review.

6

Aberrant CFTR-dependent HCO3- transport in mutations associated with cystic fibrosis.

Choi JY, Muallem D, Kiselyov K, Lee MG, Thomas PJ, Muallem S. Choi JY, et al. Among authors: thomas pj. Nature. 2001 Mar 1;410(6824):94-7. doi: 10.1038/35065099. Nature. 2001. PMID: 11242048 Free PMC article.

7

The crystal structure of the MJ0796 ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter.

Yuan YR, Blecker S, Martsinkevich O, Millen L, Thomas PJ, Hunt JF. Yuan YR, et al. Among authors: thomas pj. J Biol Chem. 2001 Aug 24;276(34):32313-21. doi: 10.1074/jbc.M100758200. Epub 2001 Jun 11. J Biol Chem. 2001. PMID: 11402022 Free article.

8

Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter.

Karpowich N, Martsinkevich O, Millen L, Yuan YR, Dai PL, MacVey K, Thomas PJ, Hunt JF. Karpowich N, et al. Among authors: thomas pj. Structure. 2001 Jul 3;9(7):571-86. doi: 10.1016/s0969-2126(01)00617-7. Structure. 2001. PMID: 11470432 Free article.

9

CFTR degradation and aggregation.

Corboy MJ, Thomas PJ, Wigley WC. Corboy MJ, et al. Among authors: thomas pj. Methods Mol Med. 2002;70:277-94. doi: 10.1385/1-59259-187-6:277. Methods Mol Med. 2002. PMID: 11917530 No abstract available.

10

In vitro CFTR folding assays.

Stidham RD, Wigley WC, Thomas PJ. Stidham RD, et al. Among authors: thomas pj. Methods Mol Med. 2002;70:311-22. doi: 10.1385/1-59259-187-6:311. Methods Mol Med. 2002. PMID: 11917534 No abstract available.

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