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Repetitive use of levosimendan in advanced heart failure: need for stronger evidence in a field in dire need of a useful therapy.
Pölzl G, Altenberger J, Baholli L, Beltrán P, Borbély A, Comin-Colet J, Delgado JF, Fedele F, Fontana A, Fruhwald F, Giamouzis G, Giannakoulas G, Garcia-González MJ, Gustafsson F, Kaikkonen K, Kivikko M, Kubica J, von Lewinski D, Löfman I, Malfatto G, Manito N, Martínez-Sellés M, Masip J, Merkely B, Morandi F, Mølgaard H, Oliva F, Pantev E, Papp Z, Perna GP, Pfister R, Piazza V, Bover R, Rangel-Sousa D, Recio-Mayoral A, Reinecke A, Rieth A, Sarapohja T, Schmidt G, Seidel M, Störk S, Vrtovec B, Wikström G, Yerly P, Pollesello P. Pölzl G, et al. Int J Cardiol. 2017 Sep 15;243:389-395. doi: 10.1016/j.ijcard.2017.05.081. Epub 2017 May 23. Int J Cardiol. 2017. PMID: 28571618 Free article. Review.
Repetitive use of levosimendan for treatment of chronic advanced heart failure: clinical evidence, practical considerations, and perspectives: an expert panel consensus.
Nieminen MS, Altenberger J, Ben-Gal T, Böhmer A, Comin-Colet J, Dickstein K, Edes I, Fedele F, Fonseca C, García-González MJ, Giannakoulas G, Iakobishvili Z, Jääskeläinen P, Karavidas A, Kettner J, Kivikko M, Lund LH, Matskeplishvili ST, Metra M, Morandi F, Oliva F, Parkhomenko A, Parissis J, Pollesello P, Pölzl G, Schwinger RH, Segovia J, Seidel M, Vrtovec B, Wikström G. Nieminen MS, et al. Int J Cardiol. 2014 Jun 15;174(2):360-7. doi: 10.1016/j.ijcard.2014.04.111. Epub 2014 Apr 18. Int J Cardiol. 2014. PMID: 24780540 Free article.
Efficacy and safety of intermittent repeated levosimendan infusions in advanced heart failure patients: the LAICA study.
García-González MJ, Aldea Perona A, Lara Padron A, Morales Rull JL, Martínez-Sellés M, de Mora Martin M, López Díaz J, López Fernandez S, Ortiz Oficialdegui P, Jiménez Sosa A. García-González MJ, et al. ESC Heart Fail. 2021 Dec;8(6):4820-4831. doi: 10.1002/ehf2.13670. Epub 2021 Oct 30. ESC Heart Fail. 2021. PMID: 34716753 Free PMC article. Clinical Trial.
Rationale and design of a randomized, double-blind, placebo controlled multicenter trial to study efficacy, security, and long term effects of intermittent repeated levosimendan administration in patients with advanced heart failure: LAICA study.
García-González MJ, de Mora-Martín M, López-Fernández S, López-Díaz J, Martínez-Sellés M, Romero-García J, Cordero M, Lara-Padrón A, Marrero-Rodríguez F, del Mar García-Saiz M, Aldea-Perona A; LAICA study investigators. García-González MJ, et al. Cardiovasc Drugs Ther. 2013 Dec;27(6):573-9. doi: 10.1007/s10557-013-6476-7. Cardiovasc Drugs Ther. 2013. PMID: 23887741 Free PMC article. Clinical Trial.
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