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Treatment with diphenyl-pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death.
Turriani E, Lázaro DF, Ryazanov S, Leonov A, Giese A, Schön M, Schön MP, Griesinger C, Outeiro TF, Arndt-Jovin DJ, Becker D. Turriani E, et al. Among authors: outeiro tf. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4971-E4977. doi: 10.1073/pnas.1700200114. Epub 2017 Jun 5. Proc Natl Acad Sci U S A. 2017. PMID: 28584093 Free PMC article.
α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner.
Yin G, Lopes da Fonseca T, Eisbach SE, Anduaga AM, Breda C, Orcellet ML, Szegő ÉM, Guerreiro P, Lázaro DF, Braus GH, Fernandez CO, Griesinger C, Becker S, Goody RS, Itzen A, Giorgini F, Outeiro TF, Zweckstetter M. Yin G, et al. Among authors: outeiro tf. Neurobiol Dis. 2014 Oct;70:149-61. doi: 10.1016/j.nbd.2014.06.018. Epub 2014 Jun 28. Neurobiol Dis. 2014. PMID: 24983211
Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.
Lázaro DF, Rodrigues EF, Langohr R, Shahpasandzadeh H, Ribeiro T, Guerreiro P, Gerhardt E, Kröhnert K, Klucken J, Pereira MD, Popova B, Kruse N, Mollenhauer B, Rizzoli SO, Braus GH, Danzer KM, Outeiro TF. Lázaro DF, et al. Among authors: outeiro tf. PLoS Genet. 2014 Nov 13;10(11):e1004741. doi: 10.1371/journal.pgen.1004741. eCollection 2014 Nov. PLoS Genet. 2014. PMID: 25393002 Free PMC article.
The Interplay between Alpha-Synuclein Clearance and Spreading.
Lopes da Fonseca T, Villar-Piqué A, Outeiro TF. Lopes da Fonseca T, et al. Among authors: outeiro tf. Biomolecules. 2015 Apr 14;5(2):435-71. doi: 10.3390/biom5020435. Biomolecules. 2015. PMID: 25874605 Free PMC article. Review.
Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium.
Dučić T, Carboni E, Lai B, Chen S, Michalke B, Lázaro DF, Outeiro TF, Bähr M, Barski E, Lingor P. Dučić T, et al. Among authors: outeiro tf. ACS Chem Neurosci. 2015 Oct 21;6(10):1769-79. doi: 10.1021/acschemneuro.5b00093. Epub 2015 Aug 25. ACS Chem Neurosci. 2015. PMID: 26284970
Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells.
Oliveira LM, Falomir-Lockhart LJ, Botelho MG, Lin KH, Wales P, Koch JC, Gerhardt E, Taschenberger H, Outeiro TF, Lingor P, Schüle B, Arndt-Jovin DJ, Jovin TM. Oliveira LM, et al. Among authors: outeiro tf. Cell Death Dis. 2015 Nov 26;6(11):e1994. doi: 10.1038/cddis.2015.318. Cell Death Dis. 2015. PMID: 26610207 Free PMC article.
351 results