Kulp JL 3rd - Search Results

1

Potency of a small molecule that targets the molluscum contagiosum virus processivity factor increases when conjugated to a tripeptide.

Guan H, Nuth M, Scott RW, Parker MH, Strobel ED, Reitz AB, Kulp JL 3rd, Ricciardi RP. Guan H, et al. Among authors: kulp jl 3rd. Antiviral Res. 2024 Jun;226:105899. doi: 10.1016/j.antiviral.2024.105899. Epub 2024 May 3. Antiviral Res. 2024. PMID: 38705201

2

BMaps: A Web Application for Fragment-Based Drug Design and Compound Binding Evaluation.

Bryan DR, Kulp JL Jr, Mahapatra MK, Bryan RL, Viswanathan U, Carlisle MN, Kim S, Schutte WD, Clarke KV, Doan TT, Kulp JL 3rd. Bryan DR, et al. Among authors: kulp jl 3rd. J Chem Inf Model. 2023 Jul 24;63(14):4229-4236. doi: 10.1021/acs.jcim.3c00209. Epub 2023 Jul 5. J Chem Inf Model. 2023. PMID: 37406353

3

An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity.

Roche KL, Remiszewski S, Todd MJ, Kulp JL 3rd, Tang L, Welsh AV, Barry AP, De C, Reiley WW, Wahl A, Garcia JV, Luftig MA, Shenk T, Tonra JR, Murphy EA, Chiang LW. Roche KL, et al. Among authors: kulp jl 3rd. J Clin Invest. 2023 Jun 15;133(12):e158978. doi: 10.1172/JCI158978. J Clin Invest. 2023. PMID: 37317966 Free PMC article.

4

A small molecule that targets the processivity factor of molluscum contagiosum virus has therapeutic potential.

Guan H, Nuth M, Isaacs SN, Xiao Y, Scott RW, Parker MH, Strobel ED, Kulp JL 3rd, Bailey TR, Reitz AB, Ricciardi RP. Guan H, et al. Among authors: kulp jl 3rd. Antiviral Res. 2023 Mar;211:105520. doi: 10.1016/j.antiviral.2022.105520. Epub 2023 Jan 2. Antiviral Res. 2023. PMID: 36603771 Free PMC article.

5

Herpes Simplex Virus-1 infection in human primary corneal epithelial cells is blocked by a stapled peptide that targets processive DNA synthesis.

Guan H, Nuth M, Lee V, Lin C, Mitchell CH, Lu W, Scott RW, Parker MH, Kulp JL 3rd, Reitz AB, Ricciardi RP. Guan H, et al. Among authors: kulp jl 3rd. Ocul Surf. 2021 Jan;19:313-321. doi: 10.1016/j.jtos.2020.11.001. Epub 2020 Nov 6. Ocul Surf. 2021. PMID: 33161128 Free PMC article.

6

Fragment-based design of small molecule PCSK9 inhibitors using simulated annealing of chemical potential simulations.

Guarnieri F, Kulp JL Jr, Kulp JL 3rd, Cloudsdale IS. Guarnieri F, et al. Among authors: kulp jl 3rd. PLoS One. 2019 Dec 5;14(12):e0225780. doi: 10.1371/journal.pone.0225780. eCollection 2019. PLoS One. 2019. PMID: 31805108 Free PMC article.

7

Mutation and structure guided discovery of an antiviral small molecule that mimics an essential C-Terminal tripeptide of the vaccinia D4 processivity factor.

Nuth M, Guan H, Xiao Y, Kulp JL 3rd, Parker MH, Strobel ED, Isaacs SN, Scott RW, Reitz AB, Ricciardi RP. Nuth M, et al. Among authors: kulp jl 3rd. Antiviral Res. 2019 Feb;162:178-185. doi: 10.1016/j.antiviral.2018.12.011. Epub 2018 Dec 20. Antiviral Res. 2019. PMID: 30578797 Free PMC article.

8

High-performance nanomaterials formed by rigid yet extensible cyclic β-peptide polymers.

Fears KP, Kolel-Veetil MK, Barlow DE, Bernstein N, So CR, Wahl KJ, Li X, Kulp JL 3rd, Latour RA, Clark TD. Fears KP, et al. Among authors: kulp jl 3rd. Nat Commun. 2018 Oct 5;9(1):4090. doi: 10.1038/s41467-018-06576-5. Nat Commun. 2018. PMID: 30291243 Free PMC article.

9

Hot-spot identification on a broad class of proteins and RNA suggest unifying principles of molecular recognition.

Kulp JL 3rd, Cloudsdale IS, Kulp JL Jr, Guarnieri F. Kulp JL 3rd, et al. PLoS One. 2017 Aug 24;12(8):e0183327. doi: 10.1371/journal.pone.0183327. eCollection 2017. PLoS One. 2017. PMID: 28837642 Free PMC article.

10

Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations.

Cloudsdale IS, Dickson JK Jr, Barta TE, Grella BS, Smith ED, Kulp JL 3rd, Guarnieri F, Kulp JL Jr. Cloudsdale IS, et al. Among authors: kulp jl 3rd. Bioorg Med Chem. 2017 Aug 1;25(15):3947-3963. doi: 10.1016/j.bmc.2017.05.032. Epub 2017 May 19. Bioorg Med Chem. 2017. PMID: 28601508 Free PMC article.

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