Joshi S - Search Results

1

Aminofutalosine Synthase: Evidence for Captodative and Aryl Radical Intermediates Using β-Scission and S_RN1 Trapping Reactions.

Joshi S, Mahanta N, Fedoseyenko D, Williams H, Begley TP. Joshi S, et al. J Am Chem Soc. 2017 Aug 16;139(32):10952-10955. doi: 10.1021/jacs.7b04209. Epub 2017 Aug 3. J Am Chem Soc. 2017. PMID: 28701039

2

Aminofutalosine Synthase (MqnE): A New Catalytic Motif in Radical SAM Enzymology.

Joshi S, Fedoseyenko D, Mahanta N, Begley TP. Joshi S, et al. Methods Enzymol. 2018;606:179-198. doi: 10.1016/bs.mie.2018.05.002. Epub 2018 Jul 18. Methods Enzymol. 2018. PMID: 30097092

3

Novel enzymology in futalosine-dependent menaquinone biosynthesis.

Joshi S, Fedoseyenko D, Mahanta N, Manion H, Naseem S, Dairi T, Begley TP. Joshi S, et al. Curr Opin Chem Biol. 2018 Dec;47:134-141. doi: 10.1016/j.cbpa.2018.09.015. Epub 2018 Nov 15. Curr Opin Chem Biol. 2018. PMID: 30447488 Review.

4

Antibacterial Strategy against H. pylori: Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis.

Joshi S, Fedoseyenko D, Mahanta N, Ducati RG, Feng M, Schramm VL, Begley TP. Joshi S, et al. ACS Med Chem Lett. 2019 Feb 15;10(3):363-366. doi: 10.1021/acsmedchemlett.8b00649. eCollection 2019 Mar 14. ACS Med Chem Lett. 2019. PMID: 30891141 Free PMC article.

5

Trapping and Electron Paramagnetic Resonance Characterization of the 5'dAdo^• Radical in a Radical S-Adenosyl Methionine Enzyme Reaction with a Non-Native Substrate.

Sayler RI, Stich TA, Joshi S, Cooper N, Shaw JT, Begley TP, Tantillo DJ, Britt RD. Sayler RI, et al. Among authors: joshi s. ACS Cent Sci. 2019 Nov 27;5(11):1777-1785. doi: 10.1021/acscentsci.9b00706. Epub 2019 Sep 25. ACS Cent Sci. 2019. PMID: 31807679 Free PMC article.

6

Radical SAM Enzyme HydE Generates Adenosylated Fe(I) Intermediates En Route to the [FeFe]-Hydrogenase Catalytic H-Cluster.

Tao L, Pattenaude SA, Joshi S, Begley TP, Rauchfuss TB, Britt RD. Tao L, et al. Among authors: joshi s. J Am Chem Soc. 2020 Jun 17;142(24):10841-10848. doi: 10.1021/jacs.0c03802. Epub 2020 Jun 3. J Am Chem Soc. 2020. PMID: 32434327 Free PMC article.

7

Menaquinone Biosynthesis: New Strategies to Trap Radical Intermediates in the MqnE-Catalyzed Reaction.

Joshi S, Fedoseyenko D, Sharma V, Nesbit MA, Britt RD, Begley TP. Joshi S, et al. Biochemistry. 2021 Jun 1;60(21):1642-1646. doi: 10.1021/acs.biochem.1c00181. Epub 2021 May 17. Biochemistry. 2021. PMID: 33999605

8

Menaquinone Biosynthesis: The Mechanism of 5,8-Dihydroxy-2-naphthoate Synthase (MqnD).

Manion-Sommerhalter HR, Fedoseyenko D, Joshi S, Begley TP. Manion-Sommerhalter HR, et al. Among authors: joshi s. Biochemistry. 2021 Jun 29;60(25):1947-1951. doi: 10.1021/acs.biochem.1c00257. Epub 2021 Jun 18. Biochemistry. 2021. PMID: 34143602

9

Phosphomethylpyrimidine Synthase (ThiC): Trapping of Five Intermediates Provides Mechanistic Insights on a Complex Radical Cascade Reaction in Thiamin Biosynthesis.

Sharma V, Fedoseyenko D, Joshi S, Abdelwahed S, Begley TP. Sharma V, et al. Among authors: joshi s. ACS Cent Sci. 2024 May 13;10(5):988-1000. doi: 10.1021/acscentsci.4c00125. eCollection 2024 May 22. ACS Cent Sci. 2024. PMID: 38799670 Free PMC article.

10

An Experimental Study to Evaluate the Antidepressant Effect of Zileuton and Aqueous Extract of Phyllanthus emblica in Unpredictable Chronic Mild Stress-Induced Depression in Albino Mice.

Sohal A, Joshi SS, Koli PG, Puradkar PV, Date VC. Sohal A, et al. Among authors: joshi ss. Cureus. 2024 Nov 1;16(11):e72859. doi: 10.7759/cureus.72859. eCollection 2024 Nov. Cureus. 2024. PMID: 39624549 Free PMC article.

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