Kling A - Search Results

1

Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides.

Kling A, Jantos K, Mack H, Hornberger W, Drescher K, Nimmrich V, Relo A, Wicke K, Hutchins CW, Lao Y, Marsh K, Moeller A. Kling A, et al. J Med Chem. 2017 Aug 24;60(16):7123-7138. doi: 10.1021/acs.jmedchem.7b00731. Epub 2017 Aug 15. J Med Chem. 2017. PMID: 28759231

2

Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs.

Kling A, Lange UE, Mack H, Bakker MH, Drescher KU, Hornberger W, Hutchins CW, Möller A, Müller R, Schmidt M, Unger L, Wicke K, Schellhaas K, Steiner G. Kling A, et al. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5567-73. doi: 10.1016/j.bmcl.2005.04.077. Epub 2005 Oct 10. Bioorg Med Chem Lett. 2005. PMID: 16219465

3

Mitigating the Metabolic Liability of Carbonyl Reduction: Novel Calpain Inhibitors with P1' Extension.

Kling A, Jantos K, Mack H, Hornberger W, Backfisch G, Lao Y, Nijsen M, Rendenbach-Mueller B, Moeller A. Kling A, et al. ACS Med Chem Lett. 2018 Feb 4;9(3):221-226. doi: 10.1021/acsmedchemlett.7b00494. eCollection 2018 Mar 8. ACS Med Chem Lett. 2018. PMID: 29541364 Free PMC article.

4

Discovery of ABT-957: 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability.

Jantos K, Kling A, Mack H, Hornberger W, Moeller A, Nimmrich V, Lao Y, Nijsen M. Jantos K, et al. Among authors: kling a. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1968-1973. doi: 10.1016/j.bmcl.2019.05.034. Epub 2019 May 18. Bioorg Med Chem Lett. 2019. PMID: 31133534

5

Synthesis and SAR of N-substituted dibenzazepinone derivatives as novel potent and selective alpha(V)beta(3) antagonists.

Kling A, Backfisch G, Delzer J, Geneste H, Graef C, Holzenkamp U, Hornberger W, Lange UE, Lauterbach A, Mack H, Seitz W, Subkowski T. Kling A, et al. Bioorg Med Chem Lett. 2002 Feb 11;12(3):441-6. doi: 10.1016/s0960-894x(01)00773-9. Bioorg Med Chem Lett. 2002. PMID: 11814816

6

Synthesis of highly potent and selective hetaryl ureas as integrin alpha(V)beta3-receptor antagonists.

Lange UE, Backfisch G, Delzer J, Geneste H, Graef C, Hornberger W, Kling A, Lauterbach A, Subkowski T, Zechel C. Lange UE, et al. Among authors: kling a. Bioorg Med Chem Lett. 2002 May 20;12(10):1379-82. doi: 10.1016/s0960-894x(02)00161-0. Bioorg Med Chem Lett. 2002. PMID: 11992781

7

Design and synthesis of 1,5- and 2,5-substituted tetrahydrobenzazepinones as novel potent and selective integrin alphaVbeta3 antagonists.

Kling A, Backfisch G, Delzer J, Geneste H, Graef C, Hornberger W, Lange UE, Lauterbach A, Seitz W, Subkowski T. Kling A, et al. Bioorg Med Chem. 2003 Apr 3;11(7):1319-41. doi: 10.1016/s0968-0896(02)00616-8. Bioorg Med Chem. 2003. PMID: 12628659

8

Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: 1H-pyrimidin-2-one derivatives.

Geneste H, Backfisch G, Braje W, Delzer J, Haupt A, Hutchins CW, King LL, Kling A, Teschendorf HJ, Unger L, Wernet W. Geneste H, et al. Among authors: kling a. Bioorg Med Chem Lett. 2006 Feb;16(3):490-4. doi: 10.1016/j.bmcl.2005.10.068. Epub 2005 Nov 11. Bioorg Med Chem Lett. 2006. PMID: 16290141

9

Highly potent and selective alphaVbeta3-receptor antagonists: solid-phase synthesis and SAR of 1-substituted 4-amino-1H-pyrimidin-2-ones.

Zechel C, Backfisch G, Delzer J, Geneste H, Graef C, Hornberger W, Kling A, Lange UE, Lauterbach A, Seitz W, Subkowski T. Zechel C, et al. Among authors: kling a. Bioorg Med Chem Lett. 2003 Jan 20;13(2):165-9. doi: 10.1016/s0960-894x(02)00931-9. Bioorg Med Chem Lett. 2003. PMID: 12482416

10

Design and synthesis of novel potent and selective integrin alphanubeta3 antagonists--novel synthetic routes to isoquinolinone, benzoxazinone, and quinazolinone acetates.

Seitz W, Geneste H, Backfisch G, Delzer J, Graef C, Hornberger W, Kling A, Subkowski T, Zimmermann N. Seitz W, et al. Among authors: kling a. Bioorg Med Chem Lett. 2008 Jan 15;18(2):527-31. doi: 10.1016/j.bmcl.2007.11.089. Epub 2007 Nov 28. Bioorg Med Chem Lett. 2008. PMID: 18068982

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