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The metabolic regulator mTORC1 controls terminal myeloid differentiation.
Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. Lee PY, et al. Among authors: charles jf. Sci Immunol. 2017 May 26;2(11):eaam6641. doi: 10.1126/sciimmunol.aam6641. Sci Immunol. 2017. PMID: 28763796 Free PMC article.
IL-1β-driven osteoclastogenic Tregs accelerate bone erosion in arthritis.
Levescot A, Chang MH, Schnell J, Nelson-Maney N, Yan J, Martínez-Bonet M, Grieshaber-Bouyer R, Lee PY, Wei K, Blaustein RB, Morris A, Wactor A, Iwakura Y, Lederer JA, Rao DA, Charles JF, Nigrovic PA. Levescot A, et al. Among authors: charles jf. J Clin Invest. 2021 Sep 15;131(18):e141008. doi: 10.1172/JCI141008. J Clin Invest. 2021. PMID: 34343136 Free PMC article.
mTORC1 links pathology in experimental models of Still's disease and macrophage activation syndrome.
Huang Z, You X, Chen L, Du Y, Brodeur K, Jee H, Wang Q, Linder G, Darbousset R, Cunin P, Chang MH, Wactor A, Wauford BM, Todd MJC, Wei K, Li Y, Levescot A, Iwakura Y, Pascual V, Baldwin NE, Quartier P, Li T, Gianatasio MT, Hasserjian RP, Henderson LA, Sykes DB, Mellins ED, Canna SW, Charles JF, Nigrovic PA, Lee PY. Huang Z, et al. Among authors: charles jf. Nat Commun. 2022 Nov 28;13(1):6915. doi: 10.1038/s41467-022-34480-6. Nat Commun. 2022. PMID: 36443301 Free PMC article.
CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts.
Greenblatt MB, Park KH, Oh H, Kim JM, Shin DY, Lee JM, Lee JW, Singh A, Lee KY, Hu D, Xiao C, Charles JF, Penninger JM, Lotinun S, Baron R, Ghosh S, Shim JH. Greenblatt MB, et al. Among authors: charles jf. J Exp Med. 2015 Jul 27;212(8):1283-301. doi: 10.1084/jem.20150407. Epub 2015 Jul 20. J Exp Med. 2015. PMID: 26195726 Free PMC article.
Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation.
Carey HA, Hildreth BE 3rd, Geisler JA, Nickel MC, Cabrera J, Ghosh S, Jiang Y, Yan J, Lee J, Makam S, Young NA, Valiente GR, Jarjour WN, Huang K, Rosol TJ, Toribio RE, Charles JF, Ostrowski MC, Sharma SM. Carey HA, et al. Among authors: charles jf. Bone Res. 2018 Mar 28;6:8. doi: 10.1038/s41413-018-0011-1. eCollection 2018. Bone Res. 2018. PMID: 29619268 Free PMC article.
169 results