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Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels.
Schedin-Weiss S, Inoue M, Hromadkova L, Teranishi Y, Yamamoto NG, Wiehager B, Bogdanovic N, Winblad B, Sandebring-Matton A, Frykman S, Tjernberg LO. Schedin-Weiss S, et al. Among authors: wiehager b. Alzheimers Res Ther. 2017 Aug 1;9(1):57. doi: 10.1186/s13195-017-0279-1. Alzheimers Res Ther. 2017. PMID: 28764767 Free PMC article.
Human brain proteins showing neuron-specific interactions with γ-secretase.
Inoue M, Hur JY, Kihara T, Teranishi Y, Yamamoto NG, Ishikawa T, Wiehager B, Winblad B, Tjernberg LO, Schedin-Weiss S. Inoue M, et al. Among authors: wiehager b. FEBS J. 2015 Jul;282(14):2587-99. doi: 10.1111/febs.13303. Epub 2015 Jul 2. FEBS J. 2015. PMID: 25893612 Free article.
Association of Omi/HtrA2 with γ-secretase in mitochondria.
Behbahani H, Pavlov PF, Wiehager B, Nishimura T, Winblad B, Ankarcrona M. Behbahani H, et al. Among authors: wiehager b. Neurochem Int. 2010 Nov;57(6):668-75. doi: 10.1016/j.neuint.2010.08.004. Epub 2010 Aug 10. Neurochem Int. 2010. PMID: 20705111
Increased beta-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer's disease APP670/671 mutation.
Johnston JA, Cowburn RF, Norgren S, Wiehager B, Venizelos N, Winblad B, Vigo-Pelfrey C, Schenk D, Lannfelt L, O'Neill C. Johnston JA, et al. Among authors: wiehager b. FEBS Lett. 1994 Nov 14;354(3):274-8. doi: 10.1016/0014-5793(94)01137-0. FEBS Lett. 1994. PMID: 7957938 Free article.
Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models.
Hedskog L, Pinho CM, Filadi R, Rönnbäck A, Hertwig L, Wiehager B, Larssen P, Gellhaar S, Sandebring A, Westerlund M, Graff C, Winblad B, Galter D, Behbahani H, Pizzo P, Glaser E, Ankarcrona M. Hedskog L, et al. Among authors: wiehager b. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7916-21. doi: 10.1073/pnas.1300677110. Epub 2013 Apr 25. Proc Natl Acad Sci U S A. 2013. PMID: 23620518 Free PMC article.
35 results