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GingisKHAN™ protease cleavage allows a high-throughput antibody to Fab conversion enabling direct functional assessment during lead identification of human monoclonal and bispecific IgG1 antibodies.
Moelleken J, Endesfelder M, Gassner C, Lingke S, Tomaschek S, Tyshchuk O, Lorenz S, Reiff U, Mølhøj M. Moelleken J, et al. Among authors: lorenz s. MAbs. 2017 Oct;9(7):1076-1087. doi: 10.1080/19420862.2017.1364325. Epub 2017 Aug 14. MAbs. 2017. PMID: 28805498 Free PMC article.
Rabbits transgenic for human IgG genes recapitulating rabbit B-cell biology to generate human antibodies of high specificity and affinity.
Ros F, Offner S, Klostermann S, Thorey I, Niersbach H, Breuer S, Zarnt G, Lorenz S, Puels J, Siewe B, Schueler N, Dragicevic T, Ostler D, Hansen-Wester I, Lifke V, Kaluza B, Kaluza K, van Schooten W, Buelow R, Tissot AC, Platzer J. Ros F, et al. Among authors: lorenz s. MAbs. 2020 Jan-Dec;12(1):1846900. doi: 10.1080/19420862.2020.1846900. MAbs. 2020. PMID: 33228444 Free PMC article.
Combined inhibition of tumor necrosis factor α and interleukin-17 as a therapeutic opportunity in rheumatoid arthritis: development and characterization of a novel bispecific antibody.
Fischer JA, Hueber AJ, Wilson S, Galm M, Baum W, Kitson C, Auer J, Lorenz SH, Moelleken J, Bader M, Tissot AC, Tan SL, Seeber S, Schett G. Fischer JA, et al. Among authors: lorenz sh. Arthritis Rheumatol. 2015 Jan;67(1):51-62. doi: 10.1002/art.38896. Arthritis Rheumatol. 2015. PMID: 25303306
Impact of selective anti-BMP9 treatment on tumor cells and tumor angiogenesis.
Brand V, Lehmann C, Umkehrer C, Bissinger S, Thier M, de Wouters M, Raemsch R, Jucknischke U, Haas A, Breuer S, Birzele F, Racek T, Reis M, Lorenzon E, Herting F, Stürzl M, Lorenz S, Kienast Y. Brand V, et al. Among authors: lorenz s. Mol Oncol. 2016 Dec;10(10):1603-1620. doi: 10.1016/j.molonc.2016.10.002. Mol Oncol. 2016. PMID: 28949445 Free PMC article.
Escherichia coli glutamyl-tRNA reductase. Trapping the thioester intermediate.
Schauer S, Chaturvedi S, Randau L, Moser J, Kitabatake M, Lorenz S, Verkamp E, Schubert WD, Nakayashiki T, Murai M, Wall K, Thomann HU, Heinz DW, Inokuchi H, Söll D, Jahn D. Schauer S, et al. Among authors: lorenz s. J Biol Chem. 2002 Dec 13;277(50):48657-63. doi: 10.1074/jbc.M206924200. Epub 2002 Oct 4. J Biol Chem. 2002. PMID: 12370189 Free article.
Methanopyrus kandleri glutamyl-tRNA reductase.
Moser J, Lorenz S, Hubschwerlen C, Rompf A, Jahn D. Moser J, et al. Among authors: lorenz s. J Biol Chem. 1999 Oct 22;274(43):30679-85. doi: 10.1074/jbc.274.43.30679. J Biol Chem. 1999. PMID: 10521455 Free article.
388 results