Luque FJ - Search Results

1

Design, synthesis and in vivo study of novel pyrrolidine-based 11β-HSD1 inhibitors for age-related cognitive dysfunction.

Leiva R, Griñan-Ferré C, Seira C, Valverde E, McBride A, Binnie M, Pérez B, Luque FJ, Pallàs M, Bidon-Chanal A, Webster SP, Vázquez S. Leiva R, et al. Among authors: luque fj. Eur J Med Chem. 2017 Oct 20;139:412-428. doi: 10.1016/j.ejmech.2017.08.003. Epub 2017 Aug 4. Eur J Med Chem. 2017. PMID: 28818766 Free article.

2

Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.

Camps P, El Achab R, Görbig DM, Morral J, Muñoz-Torrero D, Badia A, Eladi Baños J, Vivas NM, Barril X, Orozco M, Luque FJ. Camps P, et al. Among authors: luque fj. J Med Chem. 1999 Aug 26;42(17):3227-42. doi: 10.1021/jm980620z. J Med Chem. 1999. PMID: 10464010

3

New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.

Camps P, El Achab R, Morral J, Muñoz-Torrero D, Badia A, Baños JE, Vivas NM, Barril X, Orozco M, Luque FJ. Camps P, et al. Among authors: luque fj. J Med Chem. 2000 Nov 30;43(24):4657-66. doi: 10.1021/jm000980y. J Med Chem. 2000. PMID: 11101357

4

Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors.

Camps P, Gómez E, Muñoz-Torrero D, Badia A, Vivas NM, Barril X, Orozco M, Luque FJ. Camps P, et al. Among authors: luque fj. J Med Chem. 2001 Dec 20;44(26):4733-6. doi: 10.1021/jm010949b. J Med Chem. 2001. PMID: 11741490

5

Rational design of reversible acetylcholinesterase inhibitors.

Barril X, Kalko SG, Orozco M, Luque FJ. Barril X, et al. Among authors: luque fj. Mini Rev Med Chem. 2002 Feb;2(1):27-36. doi: 10.2174/1389557023406494. Mini Rev Med Chem. 2002. PMID: 12369955 Review.

6

Towards improved acetylcholinesterase inhibitors: a structural and computational approach.

Barril X, Orozco M, Luque FJ. Barril X, et al. Among authors: luque fj. Mini Rev Med Chem. 2001 Sep;1(3):255-66. doi: 10.2174/1389557013406828. Mini Rev Med Chem. 2001. PMID: 12369972 Review.

7

Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.

Martín-Santamaría S, Muñoz-Muriedas J, Luque FJ, Gago F. Martín-Santamaría S, et al. Among authors: luque fj. J Med Chem. 2004 Aug 26;47(18):4471-82. doi: 10.1021/jm049877p. J Med Chem. 2004. PMID: 15317459

8

Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.

Alonso D, Dorronsoro I, Rubio L, Muñoz P, García-Palomero E, Del Monte M, Bidon-Chanal A, Orozco M, Luque FJ, Castro A, Medina M, Martínez A. Alonso D, et al. Among authors: luque fj. Bioorg Med Chem. 2005 Dec 15;13(24):6588-97. doi: 10.1016/j.bmc.2005.09.029. Epub 2005 Oct 17. Bioorg Med Chem. 2005. PMID: 16230018

9

SAR and 3D-QSAR studies on thiadiazolidinone derivatives: exploration of structural requirements for glycogen synthase kinase 3 inhibitors.

Martinez A, Alonso M, Castro A, Dorronsoro I, Gelpí JL, Luque FJ, Pérez C, Moreno FJ. Martinez A, et al. Among authors: luque fj. J Med Chem. 2005 Nov 17;48(23):7103-12. doi: 10.1021/jm040895g. J Med Chem. 2005. PMID: 16279768

10

Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.

Muñoz-Ruiz P, Rubio L, García-Palomero E, Dorronsoro I, del Monte-Millán M, Valenzuela R, Usán P, de Austria C, Bartolini M, Andrisano V, Bidon-Chanal A, Orozco M, Luque FJ, Medina M, Martínez A. Muñoz-Ruiz P, et al. Among authors: luque fj. J Med Chem. 2005 Nov 17;48(23):7223-33. doi: 10.1021/jm0503289. J Med Chem. 2005. PMID: 16279781

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