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A novel bicistronic gene design couples stable cell line selection with a fucose switch in a designer CHO host to produce native and afucosylated glycoform antibodies.
Roy G, Martin T, Barnes A, Wang J, Jimenez RB, Rice M, Li L, Feng H, Zhang S, Chaerkady R, Wu H, Marelli M, Hatton D, Zhu J, Bowen MA. Roy G, et al. Among authors: li l. MAbs. 2018 Apr;10(3):416-430. doi: 10.1080/19420862.2018.1433975. Epub 2018 Feb 22. MAbs. 2018. PMID: 29400603 Free PMC article.
Accelerated cell culture process development and characterization for cilgavimab/tixagevimab (AZD7442) for the prevention and treatment of COVID-19.
Handlogten MW, Bosley S, Dunn S, Zhu J, Lee-O'Brien A, Li L, Therres J, Chakrabarti L, Khanal B, Mowery R, Arumugam S, Klover J, Taleb M, Reier J, Hatton D, Schmelzer A. Handlogten MW, et al. Among authors: li l. Biotechnol Bioeng. 2023 Feb 1. doi: 10.1002/bit.28336. Online ahead of print. Biotechnol Bioeng. 2023. PMID: 36722717
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