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Inherited Chromosomally Integrated Human Herpesvirus 6 Genomes Are Ancient, Intact, and Potentially Able To Reactivate from Telomeres.
Zhang E, Bell AJ, Wilkie GS, Suárez NM, Batini C, Veal CD, Armendáriz-Castillo I, Neumann R, Cotton VE, Huang Y, Porteous DJ, Jarrett RF, Davison AJ, Royle NJ. Zhang E, et al. J Virol. 2017 Oct 27;91(22):e01137-17. doi: 10.1128/JVI.01137-17. Print 2017 Nov 15. J Virol. 2017. PMID: 28835501 Free PMC article. Clinical Trial.
Human telomeres that carry an integrated copy of human herpesvirus 6 are often short and unstable, facilitating release of the viral genome from the chromosome.
Huang Y, Hidalgo-Bravo A, Zhang E, Cotton VE, Mendez-Bermudez A, Wig G, Medina-Calzada Z, Neumann R, Jeffreys AJ, Winney B, Wilson JF, Clark DA, Dyer MJ, Royle NJ. Huang Y, et al. Among authors: zhang e. Nucleic Acids Res. 2014 Jan;42(1):315-27. doi: 10.1093/nar/gkt840. Epub 2013 Sep 19. Nucleic Acids Res. 2014. PMID: 24057213 Free PMC article.
2,986 results