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Liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of the irreversible BTK inhibitor ibrutinib and its dihydrodiol-metabolite in plasma and its application in mouse pharmacokinetic studies.
Rood JJM, van Hoppe S, Schinkel AH, Schellens JHM, Beijnen JH, Sparidans RW. Rood JJM, et al. J Pharm Biomed Anal. 2016 Jan 25;118:123-131. doi: 10.1016/j.jpba.2015.10.033. Epub 2015 Oct 27. J Pharm Biomed Anal. 2016. PMID: 26540627
Extrahepatic metabolism of ibrutinib.
Rood JJM, Jamalpoor A, van Hoppe S, van Haren MJ, Wasmann RE, Janssen MJ, Schinkel AH, Masereeuw R, Beijnen JH, Sparidans RW. Rood JJM, et al. Invest New Drugs. 2021 Feb;39(1):1-14. doi: 10.1007/s10637-020-00970-x. Epub 2020 Jul 4. Invest New Drugs. 2021. PMID: 32623551 Free PMC article.
Liquid chromatography-tandem mass spectrometric assay for therapeutic drug monitoring of the B-Raf inhibitor encorafenib, the EGFR inhibitors afatinib, erlotinib and gefitinib and the O-desmethyl metabolites of erlotinib and gefitinib in human plasma.
Sparidans RW, Rosing H, Rood JJM, Schellens JHM, Beijnen JH. Sparidans RW, et al. Among authors: rood jjm. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 15;1033-1034:390-398. doi: 10.1016/j.jchromb.2016.09.012. Epub 2016 Sep 11. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. PMID: 27639128 No abstract available.
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