Clark K - Search Results

1

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.

Mettananda S, Fisher CA, Hay D, Badat M, Quek L, Clark K, Hublitz P, Downes D, Kerry J, Gosden M, Telenius J, Sloane-Stanley JA, Faustino P, Coelho A, Doondeea J, Usukhbayar B, Sopp P, Sharpe JA, Hughes JR, Vyas P, Gibbons RJ, Higgs DR. Mettananda S, et al. Among authors: clark k. Nat Commun. 2017 Sep 4;8(1):424. doi: 10.1038/s41467-017-00479-7. Nat Commun. 2017. PMID: 28871148 Free PMC article.

2

Phenotypic and molecular characterization of a serum-free miniature erythroid differentiation system suitable for high-throughput screening and single-cell assays.

Mettananda S, Clark K, Fisher CA, Sloane-Stanley JA, Gibbons RJ, Higgs DR. Mettananda S, et al. Among authors: clark k. Exp Hematol. 2018 Apr;60:10-20. doi: 10.1016/j.exphem.2018.01.001. Epub 2018 Jan 9. Exp Hematol. 2018. PMID: 29329925 Free article.

3

SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells.

Chagraoui H, Kristiansen MS, Ruiz JP, Serra-Barros A, Richter J, Hall-Ponselé E, Gray N, Waithe D, Clark K, Hublitz P, Repapi E, Otto G, Sopp P, Taylor S, Thongjuea S, Vyas P, Porcher C. Chagraoui H, et al. Among authors: clark k. Nat Commun. 2018 Dec 18;9(1):5375. doi: 10.1038/s41467-018-07787-6. Nat Commun. 2018. PMID: 30560907 Free PMC article.

4

Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences.

Hughes JR, Cheng JF, Ventress N, Prabhakar S, Clark K, Anguita E, De Gobbi M, de Jong P, Rubin E, Higgs DR. Hughes JR, et al. Among authors: clark k. Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9830-5. doi: 10.1073/pnas.0503401102. Epub 2005 Jul 5. Proc Natl Acad Sci U S A. 2005. PMID: 15998734 Free PMC article.

5

Comparative analysis of the alpha-like globin clusters in mouse, rat, and human chromosomes indicates a mechanism underlying breaks in conserved synteny.

Tufarelli C, Hardison R, Miller W, Hughes J, Clark K, Ventress N, Frischauf AM, Higgs DR. Tufarelli C, et al. Among authors: clark k. Genome Res. 2004 Apr;14(4):623-30. doi: 10.1101/gr.2143604. Genome Res. 2004. PMID: 15060003 Free PMC article.

6

Global gene expression analysis of human erythroid progenitors.

Merryweather-Clarke AT, Atzberger A, Soneji S, Gray N, Clark K, Waugh C, McGowan SJ, Taylor S, Nandi AK, Wood WG, Roberts DJ, Higgs DR, Buckle VJ, Robson KJ. Merryweather-Clarke AT, et al. Among authors: clark k. Blood. 2011 Mar 31;117(13):e96-108. doi: 10.1182/blood-2010-07-290825. Epub 2011 Jan 26. Blood. 2011. PMID: 21270440 Free article.

7

Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster.

Flint J, Tufarelli C, Peden J, Clark K, Daniels RJ, Hardison R, Miller W, Philipsen S, Tan-Un KC, McMorrow T, Frampton J, Alter BP, Frischauf AM, Higgs DR. Flint J, et al. Among authors: clark k. Hum Mol Genet. 2001 Feb 15;10(4):371-82. doi: 10.1093/hmg/10.4.371. Hum Mol Genet. 2001. PMID: 11157800

8

The relationship between chromosome structure and function at a human telomeric region.

Flint J, Thomas K, Micklem G, Raynham H, Clark K, Doggett NA, King A, Higgs DR. Flint J, et al. Among authors: clark k. Nat Genet. 1997 Mar;15(3):252-7. doi: 10.1038/ng0397-252. Nat Genet. 1997. PMID: 9054936

9

SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis.

Chagraoui H, Kassouf M, Banerjee S, Goardon N, Clark K, Atzberger A, Pearce AC, Skoda RC, Ferguson DJ, Watson SP, Vyas P, Porcher C. Chagraoui H, et al. Among authors: clark k. Blood. 2011 Jul 21;118(3):723-35. doi: 10.1182/blood-2011-01-328765. Epub 2011 May 19. Blood. 2011. PMID: 21596846 Free article.

10

Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR. Daniels RJ, et al. Among authors: clark k. Hum Mol Genet. 2001 Feb 15;10(4):339-52. doi: 10.1093/hmg/10.4.339. Hum Mol Genet. 2001. PMID: 11157797

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