Lai JR - Search Results

1

Mechanistic and Fc requirements for inhibition of Sudan virus entry and in vivo protection by a synthetic antibody.

Hofmann D, Zak SE, Nyakatura EK, Mittler E, Bakken RR, Chandran K, Dye JM, Lai JR. Hofmann D, et al. Among authors: lai jr. Immunol Lett. 2017 Oct;190:289-295. doi: 10.1016/j.imlet.2017.09.002. Epub 2017 Sep 8. Immunol Lett. 2017. PMID: 28890093 Free PMC article.

2

Inhibition of Ebola virus entry by a C-peptide targeted to endosomes.

Miller EH, Harrison JS, Radoshitzky SR, Higgins CD, Chi X, Dong L, Kuhn JH, Bavari S, Lai JR, Chandran K. Miller EH, et al. Among authors: lai jr. J Biol Chem. 2011 May 6;286(18):15854-61. doi: 10.1074/jbc.M110.207084. Epub 2011 Mar 16. J Biol Chem. 2011. PMID: 21454542 Free PMC article.

3

Designed protein mimics of the Ebola virus glycoprotein GP2 α-helical bundle: stability and pH effects.

Harrison JS, Higgins CD, Chandran K, Lai JR. Harrison JS, et al. Among authors: lai jr. Protein Sci. 2011 Sep;20(9):1587-96. doi: 10.1002/pro.688. Epub 2011 Aug 3. Protein Sci. 2011. PMID: 21739501 Free PMC article.

4

Marburg virus glycoprotein GP2: pH-dependent stability of the ectodomain α-helical bundle.

Harrison JS, Koellhoffer JF, Chandran K, Lai JR. Harrison JS, et al. Among authors: lai jr. Biochemistry. 2012 Mar 27;51(12):2515-25. doi: 10.1021/bi3000353. Epub 2012 Mar 12. Biochemistry. 2012. PMID: 22369502 Free PMC article.

5

Crystal structure of the Marburg virus GP2 core domain in its postfusion conformation.

Koellhoffer JF, Malashkevich VN, Harrison JS, Toro R, Bhosle RC, Chandran K, Almo SC, Lai JR. Koellhoffer JF, et al. Among authors: lai jr. Biochemistry. 2012 Oct 2;51(39):7665-75. doi: 10.1021/bi300976m. Epub 2012 Sep 19. Biochemistry. 2012. PMID: 22935026 Free PMC article.

6

Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the ebola virus envelope glycoprotein.

Koellhoffer JF, Chen G, Sandesara RG, Bale S, Saphire EO, Chandran K, Sidhu SS, Lai JR. Koellhoffer JF, et al. Among authors: lai jr. Chembiochem. 2012 Nov 26;13(17):2549-57. doi: 10.1002/cbic.201200493. Epub 2012 Oct 30. Chembiochem. 2012. PMID: 23111988 Free PMC article.

7

Conformational properties of peptides corresponding to the ebolavirus GP2 membrane-proximal external region in the presence of micelle-forming surfactants and lipids.

Regula LK, Harris R, Wang F, Higgins CD, Koellhoffer JF, Zhao Y, Chandran K, Gao J, Girvin ME, Lai JR. Regula LK, et al. Among authors: lai jr. Biochemistry. 2013 May 21;52(20):3393-404. doi: 10.1021/bi400040v. Epub 2013 May 7. Biochemistry. 2013. PMID: 23650881 Free PMC article.

8

C-peptide inhibitors of Ebola virus glycoprotein-mediated cell entry: effects of conjugation to cholesterol and side chain-side chain crosslinking.

Higgins CD, Koellhoffer JF, Chandran K, Lai JR. Higgins CD, et al. Among authors: lai jr. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5356-60. doi: 10.1016/j.bmcl.2013.07.056. Epub 2013 Aug 2. Bioorg Med Chem Lett. 2013. PMID: 23962564 Free PMC article.

9

Protein engineering strategies for the development of viral vaccines and immunotherapeutics.

Koellhoffer JF, Higgins CD, Lai JR. Koellhoffer JF, et al. Among authors: lai jr. FEBS Lett. 2014 Jan 21;588(2):298-307. doi: 10.1016/j.febslet.2013.10.014. Epub 2013 Oct 21. FEBS Lett. 2014. PMID: 24157357 Free PMC article. Review.

10

Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species.

Koellhoffer JF, Dai Z, Malashkevich VN, Stenglein MD, Liu Y, Toro R, S Harrison J, Chandran K, DeRisi JL, Almo SC, Lai JR. Koellhoffer JF, et al. Among authors: lai jr. J Mol Biol. 2014 Apr 3;426(7):1452-68. doi: 10.1016/j.jmb.2013.12.009. Epub 2013 Dec 12. J Mol Biol. 2014. PMID: 24333483 Free PMC article.

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