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4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.
Malek-Adamian E, Guenther DC, Matsuda S, Martínez-Montero S, Zlatev I, Harp J, Burai Patrascu M, Foster DJ, Fakhoury J, Perkins L, Moitessier N, Manoharan RM, Taneja N, Bisbe A, Charisse K, Maier M, Rajeev KG, Egli M, Manoharan M, Damha MJ. Malek-Adamian E, et al. J Am Chem Soc. 2017 Oct 18;139(41):14542-14555. doi: 10.1021/jacs.7b07582. Epub 2017 Oct 6. J Am Chem Soc. 2017. PMID: 28937776
Accurately Modeling the Conformational Preferences of Nucleosides.
Burai Patrascu M, Malek-Adamian E, Damha MJ, Moitessier N. Burai Patrascu M, et al. Among authors: malek adamian e. J Am Chem Soc. 2017 Oct 4;139(39):13620-13623. doi: 10.1021/jacs.7b07436. Epub 2017 Sep 25. J Am Chem Soc. 2017. PMID: 28899099
Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity.
O'Reilly D, Kartje ZJ, Ageely EA, Malek-Adamian E, Habibian M, Schofield A, Barkau CL, Rohilla KJ, DeRossett LB, Weigle AT, Damha MJ, Gagnon KT. O'Reilly D, et al. Among authors: malek adamian e. Nucleic Acids Res. 2019 Jan 25;47(2):546-558. doi: 10.1093/nar/gky1214. Nucleic Acids Res. 2019. PMID: 30517736 Free PMC article.